Herpes Simplex Virus Resistance to Acyclovir and Penciclovir After Two Decades of Antiviral Therapy

Overview

Journal Clin Microbiol Rev

Publisher American Society for Microbiology

Specialty Microbiology

Date 2003 Jan 15

PMID 12525428

Citations 143

Authors

Teresa H Bacon

Myron J Levin

Jeffry J Leary

Robert T Sarisky

David Sutton

Affiliations

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Abstract

Acyclovir, penciclovir, and their prodrugs have been widely used during the past two decades for the treatment of herpesvirus infections. In spite of the distribution of over 2.3 x 10(6) kg of these nucleoside analogues, the prevalence of acyclovir resistance in herpes simplex virus isolates from immunocompetent hosts has remained stable at approximately 0.3%. In immuncompromised patients, in whom the risk for developing resistance is much greater, the prevalence of resistant virus has also remained stable but at a higher level, typically 4 to 7%. These observations are examined in the light of characteristics of the virus, the drugs, and host factors.

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