Effects of Supratherapeutic Doses of Ebastine and Terfenadine on the QT Interval

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 2002 Dec 21

PMID 12492623

Citations 3

Authors

Marek Malik

Affiliations

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Citing Articles

A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.

Antonijoan R, Garcia-Gea C, Puntes M, Valle M, Esbri R, Fortea J Clin Drug Investig. 2007; 27(7):453-61.

PMID: 17563125 DOI: 10.2165/00044011-200727070-00002.

Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment.

Noveck R, Preston R, Swan S Clin Pharmacokinet. 2007; 46(6):525-34.

PMID: 17518511 DOI: 10.2165/00003088-200746060-00006.

Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.

Chaikin P, Gillen M, Malik M, Pentikis H, Rhodes G, Roberts D Br J Clin Pharmacol. 2005; 59(3):346-54.

PMID: 15752381 PMC: 1884782. DOI: 10.1111/j.1365-2125.2005.02348.x.

References

Malik M, Camm A . Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf. 2001; 24(5):323-51. DOI: 10.2165/00002018-200124050-00001. View

Malik M . Problems of heart rate correction in assessment of drug-induced QT interval prolongation. J Cardiovasc Electrophysiol. 2001; 12(4):411-20. DOI: 10.1046/j.1540-8167.2001.00411.x. View

Batchvarov V, Ghuran A, Smetana P, Hnatkova K, Harries M, Dilaveris P . QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability. Am J Physiol Heart Circ Physiol. 2002; 282(6):H2356-63. DOI: 10.1152/ajpheart.00860.2001. View

Gillen M, Miller B, Chaikin P, Morganroth J . Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. Br J Clin Pharmacol. 2001; 52(2):201-4. PMC: 2014528. DOI: 10.1046/j.0306-5251.2001.01345.x. View

Malik M, Farbom P, Batchvarov V, Hnatkova K, Camm A . Relation between QT and RR intervals is highly individual among healthy subjects: implications for heart rate correction of the QT interval. Heart. 2002; 87(3):220-8. PMC: 1767037. DOI: 10.1136/heart.87.3.220. View