Human and Simian Immunodeficiency Virus Capsid Proteins Are Major Viral Determinants of Early, Postentry Replication Blocks in Simian Cells

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2002 Dec 13

PMID 12477877

Citations 82

Authors

Christopher M Owens

Peter C Yang

Heinrich Gottlinger

Joseph Sodroski

Affiliations

Soon will be listed here.

Abstract

The cells of most Old World monkey species exhibit early, postentry restrictions on infection by human immunodeficiency virus type 1 (HIV-1) but not by simian immunodeficiency virus of macaques (SIV(mac)). Conversely, SIV(mac), but not HIV-1, infection is blocked in most New World monkey cells. By using chimeric HIV-1/SIV(mac) viruses capable of a single round of infection, we demonstrated that a major viral determinant of this restriction is the capsid (CA) protein. The efficiency of early events following HIV-1 and SIV(mac) entry is apparently determined by the interaction of the incoming viral CA and species-specific host factors.

Citing Articles

Capsid-dependent lentiviral restrictions.

Twentyman J, Emerman M, Ohainle M J Virol. 2024; 98(4):e0030824.

PMID: 38497663 PMC: 11019884. DOI: 10.1128/jvi.00308-24.

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning.

Cloherty A, Rader A, Compeer B, Ribeiro C Viruses. 2021; 13(2).

PMID: 33669846 PMC: 7923229. DOI: 10.3390/v13020320.

Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.

Tenthorey J, Young C, Sodeinde A, Emerman M, Malik H Elife. 2020; 9.

PMID: 32930662 PMC: 7492085. DOI: 10.7554/eLife.59988.

The small-molecule 3G11 inhibits HIV-1 reverse transcription.

Opp S, Fricke T, Shepard C, Kovalskyy D, Bhattacharya A, Herkules F Chem Biol Drug Des. 2016; 89(4):608-618.

PMID: 27748043 PMC: 5378662. DOI: 10.1111/cbdd.12886.

Understanding restriction factors and intrinsic immunity: insights and lessons from the primate lentiviruses.

Kirmaier A, Krupp A, Johnson W Future Virol. 2015; 9(5):483-497.

PMID: 26543491 PMC: 4630824. DOI: 10.2217/FVL.14.25.

References

Gallo R, Salahuddin S, Popovic M, Shearer G, Kaplan M, Haynes B . Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984; 224(4648):500-3. DOI: 10.1126/science.6200936. View

Barre-Sinoussi F, Chermann J, Rey F, Nugeyre M, Chamaret S, Gruest J . Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983; 220(4599):868-71. DOI: 10.1126/science.6189183. View

Klatzmann D, Champagne E, Chamaret S, Gruest J, Guetard D, Hercend T . T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature. 1984; 312(5996):767-8. DOI: 10.1038/312767a0. View

Daniel M, Letvin N, King N, Kannagi M, Sehgal P, Hunt R . Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science. 1985; 228(4704):1201-4. DOI: 10.1126/science.3159089. View

Maddon P, Dalgleish A, McDougal J, Clapham P, Weiss R, Axel R . The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 1986; 47(3):333-48. DOI: 10.1016/0092-8674(86)90590-8. View

Shibata R, Kawamura M, Sakai H, Hayami M, Ishimoto A, Adachi A . Generation of a chimeric human and simian immunodeficiency virus infectious to monkey peripheral blood mononuclear cells. J Virol. 1991; 65(7):3514-20. PMC: 241342. DOI: 10.1128/JVI.65.7.3514-3520.1991. View

Shibata R, Adachi A . SIV/HIV recombinants and their use in studying biological properties. AIDS Res Hum Retroviruses. 1992; 8(3):403-9. DOI: 10.1089/aid.1992.8.403. View

Li J, Lord C, Haseltine W, Letvin N, Sodroski J . Infection of cynomolgus monkeys with a chimeric HIV-1/SIVmac virus that expresses the HIV-1 envelope glycoproteins. J Acquir Immune Defic Syndr (1988). 1992; 5(7):639-46. View

Gabuzda D, Lawrence K, Langhoff E, Terwilliger E, Dorfman T, Haseltine W . Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. J Virol. 1992; 66(11):6489-95. PMC: 240141. DOI: 10.1128/JVI.66.11.6489-6495.1992. View

10.

LUBAN J, Bossolt K, FRANKE E, Kalpana G, Goff S . Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell. 1993; 73(6):1067-78. DOI: 10.1016/0092-8674(93)90637-6. View

11.

Yee J, Miyanohara A, Laporte P, Bouic K, Burns J, Friedmann T . A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes. Proc Natl Acad Sci U S A. 1994; 91(20):9564-8. PMC: 44853. DOI: 10.1073/pnas.91.20.9564. View

12.

FRANKE E, Yuan H, LUBAN J . Specific incorporation of cyclophilin A into HIV-1 virions. Nature. 1994; 372(6504):359-62. DOI: 10.1038/372359a0. View

13.

Thali M, Bukovsky A, Kondo E, Rosenwirth B, WALSH C, Sodroski J . Functional association of cyclophilin A with HIV-1 virions. Nature. 1994; 372(6504):363-5. DOI: 10.1038/372363a0. View

14.

Hirsch V, DApolito G, Johnson P, Elkins W, London W, Montali R . Induction of AIDS by simian immunodeficiency virus from an African green monkey: species-specific variation in pathogenicity correlates with the extent of in vivo replication. J Virol. 1995; 69(2):955-67. PMC: 188664. DOI: 10.1128/JVI.69.2.955-967.1995. View

15.

Uberla K, Stahl-Hennig C, Bottiger D, Matz-Rensing K, Kaup F, Li J . Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc Natl Acad Sci U S A. 1995; 92(18):8210-4. PMC: 41126. DOI: 10.1073/pnas.92.18.8210. View

16.

Shibata R, Sakai H, Kawamura M, Tokunaga K, Adachi A . Early replication block of human immunodeficiency virus type 1 in monkey cells. J Gen Virol. 1995; 76 ( Pt 11):2723-30. DOI: 10.1099/0022-1317-76-11-2723. View

17.

Braaten D, FRANKE E, LUBAN J . Cyclophilin A is required for an early step in the life cycle of human immunodeficiency virus type 1 before the initiation of reverse transcription. J Virol. 1996; 70(6):3551-60. PMC: 190230. DOI: 10.1128/JVI.70.6.3551-3560.1996. View

18.

Himathongkham S, Luciw P . Restriction of HIV-1 (subtype B) replication at the entry step in rhesus macaque cells. Virology. 1996; 219(2):485-8. DOI: 10.1006/viro.1996.0276. View

19.

Feng Y, Broder C, Kennedy P, BERGER E . HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 1996; 272(5263):872-7. DOI: 10.1126/science.272.5263.872. View

20.

Braaten D, FRANKE E, LUBAN J . Cyclophilin A is required for the replication of group M human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIV(CPZ)GAB but not group O HIV-1 or other primate immunodeficiency viruses. J Virol. 1996; 70(7):4220-7. PMC: 190352. DOI: 10.1128/JVI.70.7.4220-4227.1996. View