Glucocorticoids and Central Nervous System Inflammation

Overview

Journal J Neurovirol

Publisher Springer

Specialties Microbiology
Neurology

Date 2002 Dec 12

PMID 12476346

Citations 8

Authors

Klaus Dinkel

William O Ogle

Robert M Sapolsky

Affiliations

Soon will be listed here.

Abstract

Glucocorticoids (GCs) are well known for their anti-inflammatory and immunosuppressive properties in the periphery and are therefore widely and successfully used in the treatment of autoimmune diseases, chronic inflammation, or transplant rejection. This led to the assumption that GCs are uniformly anti-inflammatory in the periphery and the central nervous system (CNS). As a consequence, GCs are also used in the treatment of CNS inflammation. There is abundant evidence that an inflammatory reaction is mounted within the CNS following trauma, stroke, infection, and seizure, which can augment the brain damage. However an increasing number of studies indicate that the concept of GCs being universally immunosuppressive might be oversimplified. This article provides a review of the current literature, showing that under certain circumstances GCs might fail to have anti-inflammatory effects and sometimes even enhance inflammation.

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