Structural Chemistry and In Vitro Antitubercular Activity of Acetylpyridine Benzoyl Hydrazone and Its Copper Complex Against Mycobacterium Smegmatis

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2002 Dec 7

PMID 12467615

Citations 21

Authors

Jayendra Patole

Uday Sandbhor

Subhash Padhye

Dileep N Deobagkar

Christopher E Anson

Annie Powell

Affiliations

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Abstract

Acetylpyridine benzoyl hydrazone (APBH) 1 and its copper complex [[(APBH)CuCl](2)].(EtOH) 2 were structurally characterized by elemental analysis, magnetic measurements, spectroscopy, electrochemistry and single crystal X-ray diffraction studies. The ligand assumes Z-isomeric form and planar geometry in solid state, coordinating through pyridyl nitrogen, azomethine nitrogen and the carbonyl oxygen of the benzoyl group. The copper complex is dimeric and has a distorted octahedral geometry in which the two copper atoms are bridged by two chloride atoms. Antimycobacterial screening of ligand and its copper compound against Mycobacterium smegmatis shows clear enhancement in the antitubercular activity upon copper complexation.

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