Reciprocal Synaptic Relationships Between Orexin- and Melanin-concentrating Hormone-containing Neurons in the Rat Lateral Hypothalamus: a Novel Circuit Implicated in Feeding Regulation

Overview

Journal Int J Obes Relat Metab Disord

Date 2002 Dec 4

PMID 12461668

Citations 44

Authors

J-L Guan

K Uehara

S Lu

Q-p Wang

H Funahashi

T Sakurai

M Yanagizawa

S Shioda

Affiliations

Soon will be listed here.

Abstract

Objective: Both orexin (ORX)- and melanin-concentrating hormone (MCH) are expressed in different neurons in the lateral hypothalamic area (LH), and are considered to have common effects on stimulating food intake. There are no reports to demonstrate neural interactions between them at the ultrastructural level. We observed these neurons in the LH to evaluate the relationships between them.

Design: We used two different types of double immunostaining to reveal the ultrastructure of both the ORX- and MCH-containing neurons. A preembedding double immunostaining technique was used to study the synaptic relationships between the two kinds of neuron.

Results: The main new findings are as follows: 1) Both ORX- and MCH-containing neurons received other synaptic input and made synaptic input to other neurons; 2) Reciprocal synaptic relationships were observed between the ORX- and MCH-containing neurons.

Conclusion: The ORX- and MCH-containing neurons in the lateral hypothalamic area may influence food intake through synapse with each other.

Citing Articles

Characterization of Hypothalamic MCH Neuron Development in a 3D Differentiation System of Mouse Embryonic Stem Cells.

Kodani Y, Kawata M, Suga H, Kaneko Y, Nakashima A, Kameyama T eNeuro. 2022; 9(2).

PMID: 35437265 PMC: 9047030. DOI: 10.1523/ENEURO.0442-21.2022.

From Molecule to Behavior: Hypocretin/orexin Revisited From a Sex-dependent Perspective.

Gao X, Horvath T Endocr Rev. 2021; 43(4):743-760.

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Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis.

Al-Massadi O, Dieguez C, Schneeberger M, Lopez M, Schwaninger M, Prevot V Nat Rev Endocrinol. 2021; 17(12):745-755.

PMID: 34608277 DOI: 10.1038/s41574-021-00559-1.

Melanin-concentrating hormone and food intake control: Sites of action, peptide interactions, and appetition.

Lord M, Subramanian K, Kanoski S, Noble E Peptides. 2020; 137:170476.

PMID: 33370567 PMC: 8025943. DOI: 10.1016/j.peptides.2020.170476.

The dynamic regulation of appetitive behavior through lateral hypothalamic orexin and melanin concentrating hormone expressing cells.

Lee J, Raycraft L, Johnson A Physiol Behav. 2020; 229:113234.

PMID: 33130035 PMC: 8041470. DOI: 10.1016/j.physbeh.2020.113234.