Occurrence of HCC in Asymptomatic HCV-related Chronic Hepatitis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2002 Nov 28

PMID 12452370

Citations 3

Authors

Marcello Persico

Bruno Palmentieri

Leonardo Coppola

Giovanni Di Giacomo Russo

Fedele De Marino

Ilario de Sio

Roberto Torella

Affiliations

Soon will be listed here.

Abstract

Patients with persistently normal ALT affected with HCV-related chronic hepatitis exist. The natural history of liver disease in these patients was demonstrated to be very slow and progression to cirrhosis likely absent. The case we report describes the occurrence of hepatocellular carcinoma (HCC) in a patient with persistently normal ALT affected with mild chronic hepatitis. This observation suggests that asymptomatic carriers of HCV may develop HCC that is not related to underlying liver cirrhosis.

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References

El-Refaie A, Savage K, Bhattacharya S, Khakoo S, Harrison T, El-Batanony M . HCV-associated hepatocellular carcinoma without cirrhosis. J Hepatol. 1996; 24(3):277-85. DOI: 10.1016/s0168-8278(96)80005-5. View

Di Bisceglie A . Hepatitis C and hepatocellular carcinoma. Semin Liver Dis. 1995; 15(1):64-9. DOI: 10.1055/s-2007-1007263. View

Sangiovanni A, Morales R, Spinzi G, Rumi M, Casiraghi A, Ceriani R . Interferon alfa treatment of HCV RNA carriers with persistently normal transaminase levels: a pilot randomized controlled study. Hepatology. 1998; 27(3):853-6. DOI: 10.1002/hep.510270330. View

Persico M, Persico E, Suozzo R, Conte S, De Seta M, Coppola L . Natural history of hepatitis C virus carriers with persistently normal aminotransferase levels. Gastroenterology. 2000; 118(4):760-4. DOI: 10.1016/s0016-5085(00)70145-4. View

Trevisani F, DIntino P, Caraceni P, Pizzo M, Stefanini G, Mazziotti A . Etiologic factors and clinical presentation of hepatocellular carcinoma. Differences between cirrhotic and noncirrhotic Italian patients. Cancer. 1995; 75(9):2220-32. DOI: 10.1002/1097-0142(19950501)75:9<2220::aid-cncr2820750906>3.0.co;2-4. View

Colombo M, de Franchis R, Del Ninno E, Sangiovanni A, De Fazio C, Tommasini M . Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med. 1991; 325(10):675-80. DOI: 10.1056/NEJM199109053251002. View

Sakamuro D, Furukawa T, Takegami T . Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol. 1995; 69(6):3893-6. PMC: 189112. DOI: 10.1128/JVI.69.6.3893-3896.1995. View

Kasahara A, Hayashi N, Mochizuki K, Takayanagi M, Yoshioka K, Kakumu S . Risk factors for hepatocellular carcinoma and its incidence after interferon treatment in patients with chronic hepatitis C. Osaka Liver Disease Study Group. Hepatology. 1998; 27(5):1394-402. DOI: 10.1002/hep.510270529. View

Ray R, Lagging L, Meyer K, Steele R, Ray R . Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 1995; 37(3):209-20. DOI: 10.1016/0168-1702(95)00034-n. View

10.

De Mitri M, Poussin K, Baccarini P, Pontisso P, DErrico A, Simon N . HCV-associated liver cancer without cirrhosis. Lancet. 1995; 345(8947):413-5. DOI: 10.1016/s0140-6736(95)90400-x. View

11.

Caporaso N, Romano M, Marmo R, de Sio I, Morisco F, Minerva A . Hepatitis C virus infection is an additive risk factor for development of hepatocellular carcinoma in patients with cirrhosis. J Hepatol. 1991; 12(3):367-71. DOI: 10.1016/0168-8278(91)90841-x. View

12.

Gerber M . Relation of hepatitis C virus to hepatocellular carcinoma. J Hepatol. 1993; 17 Suppl 3:S108-11. DOI: 10.1016/s0168-8278(05)80433-7. View

13.

Johnson P, Williams R . Cirrhosis and the aetiology of hepatocellular carcinoma. J Hepatol. 1987; 4(1):140-7. DOI: 10.1016/s0168-8278(87)80021-1. View

14.

Popper H, Shafritz D, Hoofnagle J . Relation of the hepatitis B virus carrier state to hepatocellular carcinoma. Hepatology. 1987; 7(4):764-72. DOI: 10.1002/hep.1840070425. View

15.

Alberti A, Morsica G, Chemello L, Cavalletto D, Noventa F, Pontisso P . Hepatitis C viraemia and liver disease in symptom-free individuals with anti-HCV. Lancet. 1992; 340(8821):697-8. DOI: 10.1016/0140-6736(92)92234-7. View

16.

Puoti C, Magrini A, Stati T, Rigato P, Montagnese F, Rossi P . Clinical, histological, and virological features of hepatitis C virus carriers with persistently normal or abnormal alanine transaminase levels. Hepatology. 1997; 26(6):1393-8. DOI: 10.1053/jhep.1997.v26.pm0009397976. View

17.

Grando-Lemaire V, Guettier C, Chevret S, Beaugrand M, Trinchet J . Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver. Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire. J Hepatol. 1999; 31(3):508-13. DOI: 10.1016/s0168-8278(99)80044-0. View

18.

Shindo M, Arai K, SOKAWA Y, Okuno T . The virological and histological states of anti-hepatitis C virus-positive subjects with normal liver biochemical values. Hepatology. 1995; 22(2):418-25. View