Viral and Immunological Determinants of Hepatitis C Virus Clearance, Persistence, and Disease

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2002 Nov 21

PMID 12441397

Citations 245

Authors

Robert Thimme

Jens Bukh

Hans Christian Spangenberg

Stefan Wieland

Janell Pemberton

Carola Steiger

Sugantha Govindarajan

Robert H Purcell

Francis V Chisari

Affiliations

Soon will be listed here.

Abstract

To define the early events that determine the outcome of acute hepatitis C virus (HCV) infection, we compared the course of viremia with the peripheral and intrahepatic T cell response and intrahepatic cytokine profile in six acutely infected chimpanzees. Three different outcomes were observed after peak viral titers were reached: sustained viral clearance, transient viral clearance followed by chronic infection, and chronic infection that persisted at initial peak titers. The results indicate that HCV spread outpaces the T cell response and that HCV rapidly induces but is not controlled by IFN-alphabeta; that viral clearance follows the entry and accumulation of HCV-specific IFN-gamma-producing T cells in the liver; and that it may not require the destruction of infected cells.

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