Telomeres, Sex, Reactive Oxygen Species, and Human Cardiovascular Aging

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2002 Nov 19

PMID 12436345

Citations 53

Authors

Abraham Aviv

Affiliations

Soon will be listed here.

Abstract

By undergoing erosion with each replicative cycle, telomeres chronicle the replicative history of human somatic cells in vitro and in vivo. In human beings the telomere is relatively short, inversely correlated with age, highly heritable, and longer in women than men. However, it is not established whether the dynamics of telomere attrition in vivo has a role in the biology of human aging. Telomere attrition may be modified by reactive oxygen species, the biology of which is governed by processes that are influenced by sex. Indices of cardiovascular aging in humans are correlated with telomere length and this relationship is characterized by sexual dimorphism. In the final analysis, the biology of reactive oxygen species may offer a common explanation for some interindividual variation in cardiovascular aging and age-dependent telomere attrition in humans.

Citing Articles

Mitigating cellular aging and enhancing cognitive functionality: visual arts-mediated Cognitive Activation Therapy in neurocognitive disorders.

Campisi M, Cannella L, Celik D, Gabelli C, Gollin D, Simoni M Front Aging Neurosci. 2024; 16:1354025.

PMID: 38524114 PMC: 10957554. DOI: 10.3389/fnagi.2024.1354025.

Connections between cross-tissue and intra-tissue biomarkers of aging biology in older adults.

Waziry R, Gu Y, Williams O, Hagg S Epigenetics Commun. 2023; 3(1).

PMID: 38037563 PMC: 10688599. DOI: 10.1186/s43682-023-00022-4.

Shortening of leucocyte telomere length is independently correlated with high body mass index and subcutaneous obesity (predominantly truncal), in Asian Indian women with abnormal fasting glycemia.

Bhatt S, Misra A, Pandey R, Upadhyay A BMJ Open Diabetes Res Care. 2022; 10(4).

PMID: 35835478 PMC: 9289012. DOI: 10.1136/bmjdrc-2021-002706.

Gender Differences in Perceived Stress and Its Relationship to Telomere Length in Costa Rican Adults.

Mendez-Chacon E Front Psychol. 2022; 13:712660.

PMID: 35282254 PMC: 8915848. DOI: 10.3389/fpsyg.2022.712660.

Sexual Dimorphism in Telomere Length in Childhood Autism.

Panahi Y, Moghaddam F, Babaei K, Eftekhar M, Badv R, Eskandari M J Autism Dev Disord. 2022; 53(5):2050-2061.

PMID: 35220523 DOI: 10.1007/s10803-022-05486-2.