Two Pathways to NF-kappaB

Overview

Journal Mol Cell

Publisher Cell Press

Specialty Cell Biology

Date 2002 Nov 7

PMID 12419209

Citations 144

Authors

Joel L Pomerantz

David Baltimore

Affiliations

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Abstract

NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune disease.

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