Gender Dimorphism in Immune Responses Following Trauma and Hemorrhage

Overview

Journal Immunol Res

Specialty Allergy & Immunology

Date 2002 Oct 31

PMID 12403346

Citations 15

Authors

Yukihiro Yokoyama

Martin G Schwacha

T S Anantha Samy

Kirby I Bland

Irshad H Chaudry

Affiliations

Soon will be listed here.

Abstract

Previous studies have shown marked immunosuppression in males after trauma and hemorrhage. By contrast, immunosuppression was not evident in proestrous female animals. Further support for these findings came from studies demonstrating the immunosuppressive effects of male sex hormones and immunoenhancing effects of female sex hormones. In this regard, administration of 17beta-estradiol or prolactin to male animals after trauma and hemorrhage significantly improved immune function. Furthermore, castration or androgen receptor blockade with flutamide after trauma and hemorrhage in male mice showed similar beneficial effects. Thus, regulation of sex hormone synthesis or their receptor activity appears to be a useful therapeutic approach for patients to cope with the deleterious sequelae of severe trauma and hemorrhage.

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