Gut Mucosal Immunity to Tissue Transglutaminase in Untreated Celiac Disease and Other Gastrointestinal Disorders

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2002 Oct 25

PMID 12395906

Citations 1

Authors

Anna Dahele

Marian C Aldhous

Kathleen Kingstone

Kennneth Humphreys

John Bode

Margaret McIntyre

Subrata Ghosh

Affiliations

Soon will be listed here.

Abstract

Tissue transglutaminase antibodies have not previously been measured in gut secretions. IgA anti-tissue transglutaminase and anti-endomysium antibodies were measured in paired serum and whole gut lavage fluid samples from patients with untreated celiac disease (N = 36), other gastrointestinal diseases (N = 235), and healthy volunteers (N = 13). HLA DQ2 typing was performed in the celiac patients. Whole gut lavage IgA anti-tissue transglutaminase antibody concentrations were raised in 83% of celiac patients, 4% of disease controls, and 8% of volunteers, and the antibody concentrations were significantly higher in celiac patients than in controls (P < 0.0001). Whole gut lavage IgA anti-endomysium antibodies were positive in 67% of celiac patients, but in none of the controls. Whole gut lavage, but not serum, IgA anti-tissue transglutaminase antibody concentrations were significantly higher in DQ2 positive than negative celiac patients. In conclusion, whole gut lavage IgA anti-tissue transglutaminase antibody concentrations are higher in untreated celiac disease than in other gastrointestinal diseases.

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