Marian C Aldhous
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Explore the profile of Marian C Aldhous including associated specialties, affiliations and a list of published articles.
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15
Citations
630
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Recent Articles
1.
Aldhous M, Bhatia R, Pollock R, Vragkos D, Cuschieri K, Cubie H, et al.
Wellcome Open Res
. 2019 Apr;
4:48.
PMID: 30984880
We aimed to investigate whether infection with high-risk (HR) types of human papilloma virus (HPV) or HPV-associated cervical disease were associated with preterm birth (<37 weeks gestation). In a sub-group...
2.
Aldhous M
Frontline Gastroenterol
. 2017 Aug;
3(3):180-186.
PMID: 28839661
A recent research workshop gave an update on the genetics of the inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis. This mini-review summarises the updates of the gene-environmental interactions,...
3.
Aldhous M, Satsangi J
Frontline Gastroenterol
. 2017 Aug;
1(3):156-164.
PMID: 28839569
Smoking habit is the most widely accepted environmental factor affecting the incidence and disease progression in the inflammatory bowel diseases. The contrasting effects in Crohn's disease (CD) and ulcerative colitis...
4.
Aldhous M, Reynolds R, Campbell A, Linksted P, Lindsay R, Smith B, et al.
PLoS One
. 2015 Aug;
10(8):e0134883.
PMID: 26308734
Maternal diabetes in pregnancy affects offspring health. The impact of parental diabetes on offspring health is unclear. We investigated the impact of parental diabetes on the metabolic-health of adult-offspring who...
5.
Nimmo E, Prendergast J, Aldhous M, Kennedy N, Henderson P, Drummond H, et al.
Inflamm Bowel Dis
. 2011 Oct;
18(5):889-99.
PMID: 22021194
Background: Germline variation in the 71 Crohn's disease (CD) loci implicated by genome-wide association studies (GWAS) only accounts for approximately 25% of estimated heritability. The contribution of epigenetic alterations to...
6.
Aldhous M, Soo K, Stark L, Ulanicka A, Easterbrook J, Dunlop M, et al.
PLoS One
. 2011 Sep;
6(9):e24715.
PMID: 21931826
Background: Genetic and environmental factors influence susceptibility to Crohn's disease (CD): NOD2 is the strongest individual genetic determinant and smoking the best-characterised environmental factor. Carriage of NOD2 mutations predispose to...
7.
Nimmo E, Stevens C, Phillips A, Smith A, Drummond H, Noble C, et al.
Gastroenterology
. 2011 Jun;
141(3):972-981.e1-2.
PMID: 21699783
Background & Aims: The mechanisms by which specific mutations in NOD2/CARD15 increase the risk for Crohn's disease (CD) are unclear. We identified proteins that interact with NOD2 and investigated them...
8.
Aldhous M, Abu Bakar S, Prescott N, Palla R, Soo K, Mansfield J, et al.
Hum Mol Genet
. 2010 Sep;
19(24):4930-8.
PMID: 20858604
The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale...
9.
Aldhous M, Noble C, Satsangi J
PLoS One
. 2009 Jul;
4(7):e6285.
PMID: 19617917
Background: Human beta-defensin-2 (HBD2) is an antimicrobial peptide implicated in the pathogenesis of inflammatory bowel disease (IBD). Low copy number and concomitant low mRNA expression of the HBD2 gene have...
10.
Van Limbergen J, Russell R, Drummond H, Aldhous M, Round N, Nimmo E, et al.
Gastroenterology
. 2008 Aug;
135(4):1114-22.
PMID: 18725221
Background & Aims: Childhood-onset inflammatory bowel disease (IBD) might be etiologically different from adult-onset IBD. We analyzed disease phenotypes and progression of childhood-onset disease and compared them with characteristics of...