Multiparameter Selection of Helicobacter Pylori Antigens Identifies Two Novel Antigens with High Protective Efficacy

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2002 Oct 16

PMID 12379737

Citations 12

Authors

N Sabarth

R HURWITZ

T F Meyer

D Bumann

Affiliations

Soon will be listed here.

Abstract

A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.

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