Molecular Detection of Circulating Esophageal Squamous Cell Cancer Cells in the Peripheral Blood

Overview

Journal Clin Cancer Res

Specialty Oncology

Date 2002 Sep 17

PMID 12231531

Citations 16

Authors

Masahiko Koike

Kenji Hibi

Yasushi Kasai

Katsuki Ito

Seiji Akiyama

Akimasa Nakao

Affiliations

Soon will be listed here.

Abstract

Purpose And Experimental Design: To detect surgically resectable tumors earlier and improve the prognosis of esophageal squamous cell carcinoma patients, we examined deltaNp63 expression that was specific for squamous cell carcinoma in blood samples obtained from 43 esophageal cancer patients.

Results: Seventeen of 33 (52%) patients with primary esophageal squamous cell carcinoma and 6 of 10 (60%) patients with postoperative recurrent squamous cell carcinoma had detectable deltaNp63 expression in their peripheral blood using deltaNp63-specific reverse transcription-PCR. Furthermore, deltaNp63 is a more sensitive marker compared with other commonly used tumor markers such as squamous cell carcinoma-associated antigen and carcinoembryonic antigen.

Conclusions: This approach would be potentially useful for the monitoring of patients with this aggressive disease.

Citing Articles

Circulating Tumor Cell Enumeration for Serial Monitoring of Treatment Outcomes for Locally Advanced Esophageal Squamous Cell Carcinoma.

Ko J, Lam K, Kwong D, Wong I, Chan F, Wong C Cancers (Basel). 2023; 15(3).

PMID: 36765790 PMC: 9913330. DOI: 10.3390/cancers15030832.

Circulating tumor cells detected in follow-up predict survival outcomes in tri-modality management of advanced non-metastatic esophageal cancer: a secondary analysis of the QUINTETT randomized trial.

Yu E, Allan A, Sanatani M, Lewis D, Warner A, Dar A BMC Cancer. 2022; 22(1):746.

PMID: 35804307 PMC: 9264673. DOI: 10.1186/s12885-022-09846-0.

A Model Shows Utility in Predicting Postoperative Recurrence and Distant Metastasis in Curatively Resected Esophageal Squamous Cell Cancer.

Wang W, Chen Y, Zhang X, Xi K, Feng X, Zhang L Cancer Control. 2019; 26(1):1073274819852965.

PMID: 31146546 PMC: 6545664. DOI: 10.1177/1073274819852965.

Etiology, cancer stem cells and potential diagnostic biomarkers for esophageal cancer.

Liu K, Zhao T, Wang J, Chen Y, Zhang R, Lan X Cancer Lett. 2019; 458:21-28.

PMID: 31125642 PMC: 6597177. DOI: 10.1016/j.canlet.2019.05.018.

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

Hamdan F, Johnsen S Proc Natl Acad Sci U S A. 2018; 115(52):E12343-E12352.

PMID: 30541891 PMC: 6310858. DOI: 10.1073/pnas.1812915116.