The Hematopoietic System-specific Minor Histocompatibility Antigen HA-1 Shows Aberrant Expression in Epithelial Cancer Cells

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2002 Aug 7

PMID 12163564

Citations 19

Authors

Christoph A Klein

Martina Wilke

Jos Pool

Corine Vermeulen

Els Blokland

Elke Burghart

Sabine Krostina

Nicole Wendler

Bernward Passlick

Gert Riethmueller

Els Goulmy

Affiliations

Soon will be listed here.

Abstract

Allogeneic stem cell transplantation (SCT) can induce curative graft-versus-tumor reactions in patients with hematological malignancies and solid tumors. The graft-versus-tumor reaction after human histocompatibility leukocyte antigen (HLA)-identical SCT is mediated by alloimmune donor T cells specific for polymorphic minor histocompatibility antigens (mHags). Among these, the mHag HA-1 was found to be restricted to the hematopoietic system. Here, we report on the HA-1 ribonucleic acid expression by microdissected carcinoma tissues and by single disseminated tumor cells isolated from patients with various epithelial tumors. The HA-1 peptide is molecularly defined, as it forms an immunogenic peptide ligand with HLA-A2 on the cell membrane of carcinoma cell lines. HA-1-specific cytotoxic T cells lyse epithelial tumor cell lines in vitro, whereas normal epithelial cells are not recognized. Thus, HA-1-specific immunotherapy combined with HLA-identical allogeneic SCT may now be feasible for patients with HA-1(+) carcinomas.

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References

Butturini A, Gale R . T cell depletion in bone marrow transplantation for leukemia: current results and future directions. Bone Marrow Transplant. 1988; 3(3):185-92. View

Riggs A, Jones P . 5-methylcytosine, gene regulation, and cancer. Adv Cancer Res. 1983; 40:1-30. DOI: 10.1016/s0065-230x(08)60678-8. View

Falkenburg J, Goselink H, Van der Harst D, Faber L, de Kroon J, Brand A . Growth inhibition of clonogenic leukemic precursor cells by minor histocompatibility antigen-specific cytotoxic T lymphocytes. J Exp Med. 1991; 174(1):27-33. PMC: 2118892. DOI: 10.1084/jem.174.1.27. View

Weih F, Nitsch D, Reik A, Schutz G, Becker P . Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo. EMBO J. 1991; 10(9):2559-67. PMC: 452953. DOI: 10.1002/j.1460-2075.1991.tb07796.x. View

van Els C, DAmaro J, Pool J, Blokland E, Bakker A, van Elsen P . Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance. Immunogenetics. 1992; 35(3):161-5. DOI: 10.1007/BF00185109. View

Bird A . The essentials of DNA methylation. Cell. 1992; 70(1):5-8. DOI: 10.1016/0092-8674(92)90526-i. View

de Bueger M, Bakker A, van Rood J, van der Woude F, Goulmy E . Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens. J Immunol. 1992; 149(5):1788-94. View

Schreuder G, Pool J, Blokland E, van Els C, Bakker A, van Rood J . A genetic analysis of human minor histocompatibility antigens demonstrates Mendelian segregation independent of HLA. Immunogenetics. 1993; 38(2):98-105. DOI: 10.1007/BF00190897. View

Van der Harst D, Goulmy E, Falkenburg J, Goselink H, Brand A . Recognition of minor histocompatibility antigens on lymphocytic and myeloid leukemic cells by cytotoxic T-cell clones. Blood. 1994; 83(4):1060-6. View

10.

Boel P, Wildmann C, Sensi M, Brasseur R, Renauld J, Coulie P . BAGE: a new gene encoding an antigen recognized on human melanomas by cytolytic T lymphocytes. Immunity. 1995; 2(2):167-75. DOI: 10.1016/s1074-7613(95)80053-0. View

11.

Sporn M . The war on cancer. Lancet. 1996; 347(9012):1377-81. DOI: 10.1016/s0140-6736(96)91015-6. View

12.

Eibl B, Schwaighofer H, Nachbaur D, Marth C, Gachter A, Knapp R . Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer. Blood. 1996; 88(4):1501-8. View

13.

Goulmy E . Human minor histocompatibility antigens. Curr Opin Immunol. 1996; 8(1):75-81. DOI: 10.1016/s0952-7915(96)80108-7. View

14.

Ben-Yosef R, Or R, Nagler A, Slavin S . Graft-versus-tumour and graft-versus-leukaemia effect in patient with concurrent breast cancer and acute myelocytic leukaemia. Lancet. 1996; 348(9036):1242-3. DOI: 10.1016/S0140-6736(05)65517-1. View

15.

Houghton A, Meyers M, Chapman P . Medical treatment of metastatic melanoma. Surg Clin North Am. 1996; 76(6):1343-54. DOI: 10.1016/s0039-6109(05)70519-3. View

16.

Goulmy E . Human minor histocompatibility antigens: new concepts for marrow transplantation and adoptive immunotherapy. Immunol Rev. 1997; 157:125-40. DOI: 10.1111/j.1600-065x.1997.tb00978.x. View

17.

Hall A . Rho GTPases and the actin cytoskeleton. Science. 1998; 279(5350):509-14. DOI: 10.1126/science.279.5350.509. View

18.

den Haan J, Meadows L, Wang W, Pool J, Blokland E, Bishop T . The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science. 1998; 279(5353):1054-7. DOI: 10.1126/science.279.5353.1054. View

19.

Ueno N, Rondon G, Mirza N, Geisler D, Anderlini P, Giralt S . Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer. J Clin Oncol. 1998; 16(3):986-93. DOI: 10.1200/JCO.1998.16.3.986. View

20.

Wilke M, Pool J, den Haan J, Goulmy E . Genomic identification of the minor histocompatibility antigen HA-1 locus by allele-specific PCR. Tissue Antigens. 1998; 52(4):312-7. DOI: 10.1111/j.1399-0039.1998.tb03053.x. View