Protein Flexibility and Drug Design: How to Hit a Moving Target

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2002 Jul 23

PMID 12133719

Citations 84

Authors

Heather A Carlson

Affiliations

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Abstract

The most advanced methods for computer-aided drug design and database mining incorporate protein flexibility. Such techniques are not only needed to obtain proper results; they are also critical for dealing with the growing body of information from structural genomics.

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