Adipose Tissue Selective Insulin Receptor Knockout Protects Against Obesity and Obesity-related Glucose Intolerance
Overview
Reproductive Medicine
Authors
Affiliations
Insulin signaling in adipose tissue plays an important role in lipid storage and regulation of glucose homeostasis. Using the Cre-loxP system, we created mice with fat-specific disruption of the insulin receptor gene (FIRKO mice). These mice have low fat mass, loss of the normal relationship between plasma leptin and body weight, and are protected against age-related and hypothalamic lesion-induced obesity, and obesity-related glucose intolerance. FIRKO mice also exhibit polarization of adipocytes into populations of large and small cells, which differ in expression of fatty acid synthase, C/EBP alpha, and SREBP-1. Thus, insulin signaling in adipocytes is critical for development of obesity and its associated metabolic abnormalities, and abrogation of insulin signaling in fat unmasks a heterogeneity in adipocyte response in terms of gene expression and triglyceride storage.
Islet hormones at the intersection of glucose and amino acid metabolism.
White P, Wewer Albrechtsen N, Campbell J Nat Rev Endocrinol. 2025; .
PMID: 40055529 DOI: 10.1038/s41574-025-01100-4.
Regulation and function of insulin and insulin-like growth factor receptor signalling.
Choi E, Duan C, Bai X Nat Rev Mol Cell Biol. 2025; .
PMID: 39930003 DOI: 10.1038/s41580-025-00826-3.
A cross-sectional study in adiponectin, glucose metabolism, and body composition in cystic fibrosis.
Nielsen B, Mikkelsen C, Oturai P, Krogh-Madsen R, Katzenstein T, Ritz C Front Endocrinol (Lausanne). 2024; 15:1382241.
PMID: 39530118 PMC: 11550925. DOI: 10.3389/fendo.2024.1382241.
Baya N, Erdem I, Venkatesh S, Reibe S, Charles P, Navarro-Guerrero E medRxiv. 2024; .
PMID: 39371160 PMC: 11451655. DOI: 10.1101/2024.09.19.24313913.
Wang M, Czernik P, Lecka-Czernik B, Xu Y, Hill J bioRxiv. 2024; .
PMID: 39345425 PMC: 11429997. DOI: 10.1101/2024.09.20.614140.