Tau Function and Dysfunction in Neurons: Its Role in Neurodegenerative Disorders

Overview

Journal Mol Neurobiol

Specialties Molecular Biology
Neurology

Date 2002 Jul 12

PMID 12109872

Citations 12

Authors

Jesus Avila

Filip Lim

Francisco Moreno

Carlos Belmonte

A Claudio Cuello

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease (AD) is the most usual neurodegenerative disorder leading to dementia in the aged human population. It is characterized by the presence of two main brain pathological hallmarks: senile plaques and neurofibrillary tangles (NFTs). NFTs are composed of fibrillar polymers of the abnormally phosphorylated cytoskeletal protein tau.

Citing Articles

Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research.

Allroggen N, Breuer H, Bachmann S, Bell M, Zempel H Methods Mol Biol. 2024; 2754:561-580.

PMID: 38512690 DOI: 10.1007/978-1-0716-3629-9_33.

Computational modeling and biomarker studies of pharmacological treatment of Alzheimer's disease (Review).

Hassan M, Abbas Q, Seo S, Shahzadi S, Al Ashwal H, Zaki N Mol Med Rep. 2018; 18(1):639-655.

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Silencing [Formula: see text] Rescues Tau Pathologies and Memory Deficits through Rescuing PP2A and Inhibiting GSK-3β Signaling in Human Tau Transgenic Mice.

Zhang Y, Ma R, Li X, Zhang J, Shi H, Wei W Front Aging Neurosci. 2014; 6:123.

PMID: 24987368 PMC: 4060416. DOI: 10.3389/fnagi.2014.00123.

S100A9 knockout decreases the memory impairment and neuropathology in crossbreed mice of Tg2576 and S100A9 knockout mice model.

Kim H, Chang K, Ha T, Kim J, Ha S, Shin K PLoS One. 2014; 9(2):e88924.

PMID: 24586443 PMC: 3934881. DOI: 10.1371/journal.pone.0088924.

RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.

Kar A, Fushimi K, Zhou X, Ray P, Shi C, Chen X Mol Cell Biol. 2011; 31(9):1812-21.

PMID: 21343338 PMC: 3133221. DOI: 10.1128/MCB.01149-10.

References

Lu P, Wulf G, Zhou X, Davies P, Lu K . The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein. Nature. 1999; 399(6738):784-8. DOI: 10.1038/21650. View

Montejo De Garcini E, Avila J . In vitro conditions for the self-polymerization of the microtubule-associated protein, tau factor. J Biochem. 1987; 102(6):1415-21. DOI: 10.1093/oxfordjournals.jbchem.a122187. View

Correas I, Diaz-Nido J, Avila J . Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain. J Biol Chem. 1992; 267(22):15721-8. View

Goedert M . Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. Philos Trans R Soc Lond B Biol Sci. 1999; 354(1386):1101-18. PMC: 1692614. DOI: 10.1098/rstb.1999.0466. View

Perez M, Lim F, Arrasate M, Avila J . The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules. J Neurochem. 2000; 74(6):2583-9. DOI: 10.1046/j.1471-4159.2000.0742583.x. View

Terry R, Masliah E, Salmon D, Butters N, DeTeresa R, Hill R . Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol. 1991; 30(4):572-80. DOI: 10.1002/ana.410300410. View

Sadot E, Gurwitz D, Barg J, Behar L, Ginzburg I, Fisher A . Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells. J Neurochem. 1996; 66(2):877-80. DOI: 10.1046/j.1471-4159.1996.66020877.x. View

Spillantini M, Goedert M . Tau protein pathology in neurodegenerative diseases. Trends Neurosci. 1998; 21(10):428-33. DOI: 10.1016/s0166-2236(98)01337-x. View

Goedert M, Spillantini M, Jakes R, Rutherford D, Crowther R . Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron. 1989; 3(4):519-26. DOI: 10.1016/0896-6273(89)90210-9. View

10.

Ledesma M, Bonay P, Colaco C, Avila J . Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem. 1994; 269(34):21614-9. View

11.

Panda D, Goode B, Feinstein S, Wilson L . Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau. Biochemistry. 1995; 34(35):11117-27. DOI: 10.1021/bi00035a017. View

12.

Lewis J, Dickson D, Lin W, Chisholm L, Corral A, Jones G . Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001; 293(5534):1487-91. DOI: 10.1126/science.1058189. View

13.

Arriagada P, Marzloff K, Hyman B . Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology. 1992; 42(9):1681-8. DOI: 10.1212/wnl.42.9.1681. View

14.

Grant S, Shankar S, Chalmers-Redman R, Tatton W, Szyf M, Cuello A . Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751). Neuroreport. 1999; 10(1):41-6. DOI: 10.1097/00001756-199901180-00008. View

15.

Kosik K, Caceres A . Tau protein and the establishment of an axonal morphology. J Cell Sci Suppl. 1991; 15:69-74. DOI: 10.1242/jcs.1991.supplement_15.10. View

16.

Kenessey A, Nacharaju P, Ko L, Yen S . Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration. J Neurochem. 1998; 69(5):2026-38. DOI: 10.1046/j.1471-4159.1997.69052026.x. View

17.

Hartmann A, Rujescu D, Giannakouros T, Nikolakaki E, Goedert M, Mandelkow E . Regulation of alternative splicing of human tau exon 10 by phosphorylation of splicing factors. Mol Cell Neurosci. 2001; 18(1):80-90. DOI: 10.1006/mcne.2001.1000. View

18.

Drubin D, Kirschner M . Tau protein function in living cells. J Cell Biol. 1986; 103(6 Pt 2):2739-46. PMC: 2114585. DOI: 10.1083/jcb.103.6.2739. View

19.

Nunez J . Immature and mature variants of MAP2 and tau proteins and neuronal plasticity. Trends Neurosci. 1988; 11(11):477-9. DOI: 10.1016/0166-2236(88)90004-5. View

20.

Goedert M, Spillantini M, Potier M, Ulrich J, Crowther R . Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain. EMBO J. 1989; 8(2):393-9. PMC: 400819. DOI: 10.1002/j.1460-2075.1989.tb03390.x. View