General Synthesis of Persistent Trityl Radicals for EPR Imaging of Biological Systems

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2002 Jul 6

PMID 12098269

Citations 62

Authors

T Jagadeeswar Reddy

Tetsuo Iwama

Howard J Halpern

Viresh H Rawal

Affiliations

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Abstract

In this paper we describe the syntheses of the tetraoxygenated triarylmethyl (trityl) radical 14 and the tetrathiatriarylmethyl (trityl) radicals 15 and 16. The syntheses include new and improved preparations of the key intermediate compounds 1 and 2. The new route to compound 2 is noteworthy for its efficiency and its avoidance of the highly toxic compound phosgene as well as the isolation of the air-sensitive 1,2,4,5-benzenetetrathiol.

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