BeadArray Technology: Enabling an Accurate, Cost-effective Approach to High-throughput Genotyping

Overview

Journal Biotechniques

Specialties Biomedical Engineering
Biotechnology

Date 2002 Jun 27

PMID 12083399

Citations 214

Authors

Arnold Oliphant

David L Barker

John R Stuelpnagel

Mark S Chee

Affiliations

Soon will be listed here.

Abstract

The Human Genome Project has opened the door to personalized medicine, provided that human genetic diversity can be analyzed in a high-throughput and cost-effective way Illumina has developed a genotyping system that combines very high throughput and accuracy with low cost per SNP analysis. The system uses our BeadArray platform, a high level of multiplexing, and modular, scalable automation to meet the requirements for cost-effective, genome-wide linkage disequilibrium studies. As implemented in a high-throughput genotyping service facility at Illumina, the system has a current capacity of one million SNP assays per day and is easily expandable. Each SNP call is associated with a quality score that correlates with accuracy

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