David L Barker
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Explore the profile of David L Barker including associated specialties, affiliations and a list of published articles.
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17
Citations
1427
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Recent Articles
1.
Serre D, Gurd S, Ge B, Sladek R, Sinnett D, Harmsen E, et al.
PLoS Genet
. 2008 May;
4(2):e1000006.
PMID: 18454203
The recent development of whole genome association studies has lead to the robust identification of several loci involved in different common human diseases. Interestingly, some of the strongest signals of...
2.
Kozlov I, Melnyk P, Hachmann J, Srinivasan A, Shults M, Zhao C, et al.
Comb Chem High Throughput Screen
. 2008 Jan;
11(1):24-35.
PMID: 18220541
We have developed a miniaturized and multiplexed solution assay for the measurement of protease activity in complex samples. This technology can accelerate research in functional proteomics and enable biologists to...
3.
Kozlov I, Melnyk P, Hachmann J, Barker D, Lebl M, Zhao C
Nucleosides Nucleotides Nucleic Acids
. 2007 Dec;
26(10-12):1353-7.
PMID: 18066782
We developed novel assays for high-throughput detection of one or many kinases or proteases. The assays use hundreds of different peptide substrates, each covalently linked to an oligonucleotide tag. After...
4.
Kozlov I, Kermani B, Melnyk P, Barker D, Zhao C, Hachmann J, et al.
J Chromatogr Sci
. 2007 May;
45(4):207-11.
PMID: 17504569
The retention of histidine-containing peptides in immobilized metal-affinity chromatography is studied using several hundred modeled peptides. Retention is driven primarily by the number of histidine residues; however, the amino acid...
5.
Shults M, Kozlov I, Nelson N, Kermani B, Melnyk P, Shevchenko V, et al.
Chembiochem
. 2007 May;
8(8):933-42.
PMID: 17471478
We report a novel protein kinase assay designed for high-throughput detection of one or many kinases in a complex mixture. A solution-phase phosphorylation reaction is performed on 900 different peptide...
6.
Peiffer D, Le J, Steemers F, Chang W, Jenniges T, Garcia F, et al.
Genome Res
. 2006 Aug;
16(9):1136-48.
PMID: 16899659
Array-CGH is a powerful tool for the detection of chromosomal aberrations. The introduction of high-density SNP genotyping technology to genomic profiling, termed SNP-CGH, represents a further advance, since simultaneous measurement...
7.
Bibikova M, Chudin E, Wu B, Zhou L, Garcia E, Liu Y, et al.
Genome Res
. 2006 Aug;
16(9):1075-83.
PMID: 16899657
Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We compared the...
8.
Kozlov I, Melnyk P, Zhao C, Hachmann J, Shevchenko V, Srinivasan A, et al.
Comb Chem High Throughput Screen
. 2006 Jul;
9(6):481-7.
PMID: 16842230
We have developed a high throughput assay for the measurement of protease activity in solution. This technology will accelerate research in functional proteomics and enable biologists to streamline protease substrate...
9.
Liu Y, Shin S, Zeng X, Zhan M, Gonzalez R, Mueller F, et al.
BMC Dev Biol
. 2006 May;
6:20.
PMID: 16672070
Background: In order to compare the gene expression profiles of human embryonic stem cell (hESC) lines and their differentiated progeny and to monitor feeder contaminations, we have examined gene expression...
10.
Bibikova M, Lin Z, Zhou L, Chudin E, Garcia E, Wu B, et al.
Genome Res
. 2006 Feb;
16(3):383-93.
PMID: 16449502
We have developed a high-throughput method for analyzing the methylation status of hundreds of preselected genes simultaneously and have applied it to the discovery of methylation signatures that distinguish normal...