Recruitment of Mammalian Cell Fibronectin to the Surface of Chlamydia Trachomatis

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2002 Jun 18

PMID 12065538

Citations 4

Authors

Betsy J Kleba

Erin Banta

Erika A Lindquist

Richard S Stephens

Affiliations

Soon will be listed here.

Abstract

Pathogenic bacteria exploit the presence of various host cell molecules in order to colonize new tissues. Fibronectin is involved in a wide range of cell functions in vivo, and staphylococci, streptococci, and gonococci have evolved mechanisms to utilize this glycoprotein to mediate host cell binding. We show that elementary bodies (EB) from two biovars of Chlamydia trachomatis recruit fibronectin to their surfaces upon lysis of the host cell. We also demonstrate that a heparan sulfate lyase-sensitive molecule on chlamydial EB is responsible for binding at least a portion of this fibronectin.

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