The Function of AID in Somatic Mutation and Class Switch Recombination: Upstream or Downstream of DNA Breaks

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2002 May 8

PMID 11994429

Citations 11

Authors

Katrin F Chua

Frederick W Alt

John P Manis

Affiliations

Soon will be listed here.

Citing Articles

System-Level Scenarios for the Elucidation of T Cell-Mediated Germinal Center B Cell Differentiation.

Verstegen N, Ubels V, Westerhoff H, van Ham S, Barberis M Front Immunol. 2021; 12:734282.

PMID: 34616402 PMC: 8488341. DOI: 10.3389/fimmu.2021.734282.

Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.

Hasham M, Snow K, Donghia N, Branca J, Lessard M, Stavnezer J J Immunol. 2012; 189(5):2374-82.

PMID: 22826323 PMC: 3424338. DOI: 10.4049/jimmunol.1200414.

Evolution of coordinated mutagenesis and somatic hypermutation in VH5.

Wright B, Schmidt K, Hunt A, Reschke D, Minnick M Mol Immunol. 2011; 49(3):537-48.

PMID: 22056943 PMC: 3235918. DOI: 10.1016/j.molimm.2011.10.001.

Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia.

Gruber T, Chang M, Sposto R, Muschen M Cancer Res. 2010; 70(19):7411-20.

PMID: 20876806 PMC: 2948648. DOI: 10.1158/0008-5472.CAN-10-1438.

AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.

Zan H, Casali P Mol Immunol. 2008; 46(1):45-61.

PMID: 18760480 PMC: 2975703. DOI: 10.1016/j.molimm.2008.07.003.

References

Petersen S, Casellas R, Reina-San-Martin B, Chen H, Difilippantonio M, Wilson P . AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching. Nature. 2001; 414(6864):660-665. PMC: 4729367. DOI: 10.1038/414660a. View

Dunnick W, Wilson M, Stavnezer J . Mutations, duplication, and deletion of recombined switch regions suggest a role for DNA replication in the immunoglobulin heavy-chain switch. Mol Cell Biol. 1989; 9(5):1850-6. PMC: 362975. DOI: 10.1128/mcb.9.5.1850-1856.1989. View

Sale J, Neuberger M . TdT-accessible breaks are scattered over the immunoglobulin V domain in a constitutively hypermutating B cell line. Immunity. 1999; 9(6):859-69. DOI: 10.1016/s1074-7613(00)80651-2. View

Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T . Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000; 102(5):553-63. DOI: 10.1016/s0092-8674(00)00078-7. View

Ward I, Chen J . Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem. 2001; 276(51):47759-62. DOI: 10.1074/jbc.C100569200. View

Winter E, Krawinkel U, Radbruch A . Directed Ig class switch recombination in activated murine B cells. EMBO J. 1987; 6(6):1663-71. PMC: 553539. DOI: 10.1002/j.1460-2075.1987.tb02415.x. View

Papavasiliou F, Schatz D . The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med. 2002; 195(9):1193-8. PMC: 2193708. DOI: 10.1084/jem.20011858. View

Papavasiliou F, Schatz D . Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Nature. 2000; 408(6809):216-21. DOI: 10.1038/35041599. View

Okazaki I, Kinoshita K, Muramatsu M, Yoshikawa K, Honjo T . The AID enzyme induces class switch recombination in fibroblasts. Nature. 2002; 416(6878):340-5. DOI: 10.1038/nature727. View

10.

Bemark M, Sale J, Kim H, Berek C, COSGROVE R, Neuberger M . Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity. J Exp Med. 2000; 192(10):1509-14. PMC: 2193187. DOI: 10.1084/jem.192.10.1509. View

11.

Manis J, Gu Y, Lansford R, Sonoda E, Ferrini R, Davidson L . Ku70 is required for late B cell development and immunoglobulin heavy chain class switching. J Exp Med. 1998; 187(12):2081-9. PMC: 2212369. DOI: 10.1084/jem.187.12.2081. View

12.

Hesslein D, Schatz D . Factors and forces controlling V(D)J recombination. Adv Immunol. 2001; 78:169-232. DOI: 10.1016/s0065-2776(01)78004-2. View

13.

Revy P, Muto T, Levy Y, Geissmann F, Plebani A, Sanal O . Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell. 2000; 102(5):565-75. DOI: 10.1016/s0092-8674(00)00079-9. View

14.

Sale J, Calandrini D, Takata M, Takeda S, Neuberger M . Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation. Nature. 2001; 412(6850):921-6. DOI: 10.1038/35091100. View

15.

Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H . Ku80 is required for immunoglobulin isotype switching. EMBO J. 1998; 17(8):2404-11. PMC: 1170583. DOI: 10.1093/emboj/17.8.2404. View

16.

Bross L, Fukita Y, McBlane F, Demolliere C, Rajewsky K, Jacobs H . DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation. Immunity. 2000; 13(5):589-97. DOI: 10.1016/s1074-7613(00)00059-5. View

17.

Paull T, Rogakou E, Yamazaki V, Kirchgessner C, Gellert M, Bonner W . A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000; 10(15):886-95. DOI: 10.1016/s0960-9822(00)00610-2. View

18.

Gu H, Zou Y, Rajewsky K . Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993; 73(6):1155-64. DOI: 10.1016/0092-8674(93)90644-6. View

19.

Dunnick W, Hertz G, Scappino L, Gritzmacher C . DNA sequences at immunoglobulin switch region recombination sites. Nucleic Acids Res. 1993; 21(3):365-72. PMC: 309126. DOI: 10.1093/nar/21.3.365. View

20.

Muramatsu M, Sankaranand V, Anant S, Sugai M, Kinoshita K, Davidson N . Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem. 1999; 274(26):18470-6. DOI: 10.1074/jbc.274.26.18470. View