BH3-only Proteins - Evolutionarily Conserved Proapoptotic Bcl-2 Family Members Essential for Initiating Programmed Cell Death

Overview

Journal J Cell Sci

Specialty Cell Biology

Date 2002 Apr 16

PMID 11950875

Citations 97

Authors

Philippe Bouillet

Andreas Strasser

Affiliations

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Abstract

The BH3-only members of the Bcl-2 protein family are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating the protective function of the pro-survival members of the Bcl-2 family and by activating the Bax/Bax-like pro-apoptotic family members.

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