Reparable Sonoporation Generated by Microstreaming

Overview

Journal J Acoust Soc Am

Publisher American Institute of Physics

Specialty Otorhinolaryngology

Date 2002 Apr 5

PMID 11931323

Citations 32

Authors

Junru Wu

Joel P Ross

Jen-Fu Chiu

Affiliations

Soon will be listed here.

Abstract

Reparable sonoporation was observed in Jurkat lymphocytes in suspension exposed to a vibrating Mason horn tuned to 21.4 KHz. The diameter of the horn tip was 400 microm and its transverse displacement amplitude was 7.8 microm. It was found that the shear stress associated with microstreaming surrounding the Mason-horn tip was the primary reason for the cell reparable sonoporation. The threshold shear stress was determined to be 12 +/- 4 Pa for exposure time up to 7 min. It was also found that the shorter the exposure time, the greater the threshold.

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