Deoxyribozyme-based Logic Gates

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2002 Apr 4

PMID 11929243

Citations 71

Authors

Milan N Stojanovic

Tiffany Elizabeth Mitchell

Darko Stefanovic

Affiliations

Soon will be listed here.

Abstract

We report herein a set of deoxyribozyme-based logic gates capable of generating any Boolean function. We construct basic NOT and AND gates, followed by the more complex XOR gate. These gates were constructed through a modular design that combines molecular beacon stem-loops with hammerhead-type deoxyribozymes. Importantly, as the gates have oligonucleotides as both inputs and output, they open the possibility of communication between various computation elements in solution. The operation of these gates is conveniently connected to a fluorescent readout.

Citing Articles

Chemical unclonable functions based on operable random DNA pools.

Luescher A, Gimpel A, Stark W, Heckel R, Grass R Nat Commun. 2024; 15(1):2955.

PMID: 38580696 PMC: 10997750. DOI: 10.1038/s41467-024-47187-7.

DNA as a universal chemical substrate for computing and data storage.

Yang S, Bogels B, Wang F, Xu C, Dou H, Mann S Nat Rev Chem. 2024; 8(3):179-194.

PMID: 38337008 DOI: 10.1038/s41570-024-00576-4.

Compact RNA sensors for increasingly complex functions of multiple inputs.

Choe C, Andreasson J, Melaine F, Kladwang W, Wu M, Portela F bioRxiv. 2024; .

PMID: 38260323 PMC: 10802310. DOI: 10.1101/2024.01.04.572289.

Lipid vesicle-based molecular robots.

Peng Z, Iwabuchi S, Izumi K, Takiguchi S, Yamaji M, Fujita S Lab Chip. 2024; 24(5):996-1029.

PMID: 38239102 PMC: 10898420. DOI: 10.1039/d3lc00860f.

The Amplified DNA Logic Gates Based on Aptamer-Receptor Recognition for Cell Detection and Bioimaging.

Wang Y, Wu D, Cao X, Guo Y Biosensors (Basel). 2023; 13(11).

PMID: 37998143 PMC: 10669702. DOI: 10.3390/bios13110968.