Expression of Thymidine Phosphorylase in Primary Human Renal Cell Carcinoma by ELISA Method

Overview

Journal Jpn J Cancer Res

Specialty Oncology

Date 2002 Apr 3

PMID 11927017

Citations 2

Authors

Hidetoshi Kinsui

Takeshi Ueda

Hiroyoshi Suzuki

Shigeo Isaka

Nobuyuki Sekita

Akira Komiya

Toyofusa Tobe

Tomonori Yamanishi

Koichiro Akakura

Tomohiko Ichikawa

Tatsuo Igarashi

Haruo Ito

Affiliations

Soon will be listed here.

Abstract

Thymidine phosphorylase (TP) expression in 100 paired samples of renal cell carcinoma (RCC) and normal adjacent tissue was analyzed by an ELISA method. We also investigated whether TP expression correlates with clinicopathological findings and clinical outcomes of these patients. Median TP expression was 9-fold (range, 0.5-56) higher in primary tumor than in non-cancerous renal tissue (P < 0.0001). There was a significant difference with respect to tumor venous invasion. TP expression was significantly higher in patients with such venous invasion than in those without (P = 0.018). However, there was no correlation between TP level and other clinicopathological findings and the survival curves. These results suggest that ELISA is useful for evaluating TP expression of human RCC and may provide a novel approach to therapy for patients with RCC.

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