Thymidine Phosphorylase/platelet-derived Endothelial Cell Growth Factor Expression Associated with Hepatic Metastasis in Gastric Carcinoma

Overview

Journal Br J Cancer

Specialty Oncology

Date 1996 Apr 1

PMID 8611421

Citations 32

Authors

K Maeda

Y S Chung

Y Ogawa

S Takatsuka

S M Kang

M Ogawa

T Sawada

N Onoda

Y Kato

M Sowa

Affiliations

Soon will be listed here.

Abstract

It is known that angiogenesis plays an important role in the growth and metastasis of solid tumours. Several angiogenic factors have been identified and platelet-derived endothelial cell growth factor (PD-ECGF) is thought to be one such factor. Recently, it was reported that thymidine phosphorylase (dThdPase) is identical to PD-ECGF. Using immunohistochemical staining with an anti-dThdPase antibody, we investigated the correlation between dThdPase expression and the microvessel density in 120 gastric carcinomas. The microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in dThdPase-positive tumours than in dThdPase-negative tumors. There was a significant correlation between dThdPase expression and the increment of microvessel density. Moreover, regarding distant organ metastasis, the frequency of hepatic metastasis was significantly higher (P < 0.01) in patients with dThdPase-positive tumours than in those with dThdPase-negative tumors. In summary, it was suggested that dThdPase expression is closely associated with the promotion of angiogenesis and hepatic metastasis in gastric carcinoma.

Citing Articles

Astrogliosis in multiple sclerosis and neuro-inflammation: what role for the notch pathway?.

Mora P, Chapouly C Front Immunol. 2023; 14:1254586.

PMID: 37936690 PMC: 10627009. DOI: 10.3389/fimmu.2023.1254586.

Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer.

Shimizu D, Kanda M, Kodera Y World J Gastrointest Oncol. 2018; 10(6):124-136.

PMID: 29988904 PMC: 6033711. DOI: 10.4251/wjgo.v10.i6.124.

Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions.

Chapouly C, Argaw A, Horng S, Castro K, Zhang J, Asp L Brain. 2015; 138(Pt 6):1548-67.

PMID: 25805644 PMC: 4614128. DOI: 10.1093/brain/awv077.

Thymidine phosphorylase mRNA expression may be a predictor of response to post-operative adjuvant chemotherapy with S-1 in patients with stage III colorectal cancer.

Ogawa M, Watanabe M, Mitsuyama Y, Anan T, Ohkuma M, Kobayashi T Oncol Lett. 2014; 8(6):2463-2468.

PMID: 25364408 PMC: 4214505. DOI: 10.3892/ol.2014.2574.

Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers.

Maw M, Fujimoto J, Tamaya T Exp Ther Med. 2012; 1(2):351-356.

PMID: 22993548 PMC: 3445945. DOI: 10.3892/etm_00000055.

References

Liotta L, Saidel M, KLEINERMAN J . The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res. 1976; 36(3):889-94. View

Toi M, Hoshina S, Taniguchi T, Yamamoto Y, Ishitsuka H, Tominaga T . Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer. Int J Cancer. 1995; 64(2):79-82. DOI: 10.1002/ijc.2910640202. View

Miwa M, Nishimura J, Kamiyama T, Ishitsuka H . [Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients]. Gan To Kagaku Ryoho. 1987; 14(10):2924-9. View

Nagy J, Brown L, Senger D, Lanir N, Van de Water L, Dvorak A . Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta. 1989; 948(3):305-26. DOI: 10.1016/0304-419x(89)90004-8. View

Ishikawa F, Miyazono K, Hellman U, Drexler H, Wernstedt C, Hagiwara K . Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature. 1989; 338(6216):557-62. DOI: 10.1038/338557a0. View

Zagzag D, Miller D, Sato Y, Rifkin D, Burstein D . Immunohistochemical localization of basic fibroblast growth factor in astrocytomas. Cancer Res. 1990; 50(22):7393-8. View

Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K . Angiogenic factor. Nature. 1992; 356(6371):668. DOI: 10.1038/356668a0. View

Usuki K, Saras J, Waltenberger J, Miyazono K, Pierce G, Thomason A . Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. Biochem Biophys Res Commun. 1992; 184(3):1311-6. DOI: 10.1016/s0006-291x(05)80025-7. View

Bosari S, Lee A, DeLellis R, Wiley B, Heatley G, Silverman M . Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol. 1992; 23(7):755-61. DOI: 10.1016/0046-8177(92)90344-3. View

10.

Folkman J . The role of angiogenesis in tumor growth. Semin Cancer Biol. 1992; 3(2):65-71. View

11.

Weidner N, Folkman J, Pozza F, Bevilacqua P, Allred E, Moore D . Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst. 1992; 84(24):1875-87. DOI: 10.1093/jnci/84.24.1875. View

12.

Gasparini G, Weidner N, Bevilacqua P, Maluta S, Dalla Palma P, Caffo O . Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol. 1994; 12(3):454-66. DOI: 10.1200/JCO.1994.12.3.454. View

13.

Haraguchi M, Miyadera K, Uemura K, Sumizawa T, Furukawa T, Yamada K . Angiogenic activity of enzymes. Nature. 1994; 368(6468):198. DOI: 10.1038/368198a0. View

14.

Fujii Y, Itoyanagi H, Saegusa Y, Hasumi K, Eriguchi M . [Effects of 5'-DFUR against BALB/c retroperitoneal sarcoma with spontaneous liver metastases]. Gan To Kagaku Ryoho. 1994; 21(10):1627-31. View

15.

Toi M, Hoshina S, Takayanagi T, Tominaga T . Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relapse in primary breast cancer. Jpn J Cancer Res. 1994; 85(10):1045-9. PMC: 5919354. DOI: 10.1111/j.1349-7006.1994.tb02904.x. View

16.

Maeda K, Chung Y, Takatsuka S, Ogawa Y, Sawada T, Yamashita Y . Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol. 1995; 13(2):477-81. DOI: 10.1200/JCO.1995.13.2.477. View

17.

Ishitsuka H, Miwa M, Takemoto K, Fukuoka K, Itoga A, Maruyama H . Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine. Gan. 1980; 71(1):112-23. View