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Histone Methylation in Transcriptional Control

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 2002 Mar 15
PMID 11893494
Citations 321
Authors
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Abstract

Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones. Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.

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