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Opioid Tolerance-in Search of the Holy Grail

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2002 Mar 15
PMID 11893329
Citations 59
Authors
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Abstract

Tolerance, one of several behavioral adaptations to prolonged opioid treatment, has long been explained by desensitization of opioid receptor signaling and loss of surface receptors. However, recent evidence presents an alternative hypothesis, suggesting that receptor internalization could in fact reduce tolerance in vivo.

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