Effect of Exogenous Interleukin-18 (IL-18) and IL-12 in the Course of Brucella Abortus 2308 Infection in Mice

Overview

Journal Clin Diagn Lab Immunol

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2002 Mar 5

PMID 11874900

Citations 5

Authors

Paolo Pasquali

Rosanna Adone

Louis C Gasbarre

Claudia Pistoia

Franco Ciuchini

Affiliations

Soon will be listed here.

Abstract

In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.

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