Methylation Status of Oestrogen Receptor-alpha Gene Promoter Sequences in Human Ovarian Epithelial Cell Lines

Overview

Journal Br J Cancer

Specialty Oncology

Date 2002 Mar 1

PMID 11870520

Citations 8

Authors

A M ODoherty

S W Church

S E H Russell

J Nelson

I Hickey

Affiliations

Soon will be listed here.

Abstract

We have determined the methylation status of the CpG island of the oestrogen receptor alpha gene in seven human ovarian cell lines. Cell lines expressing oestrogen receptor alpha showed no evidence of hypermethylation. In three of four cell lines that produced no detectable oestrogen receptor alpha protein, hypermethylation was observed at the NotI site of the CpG island. These results indicate that aberrant hypermethylation may be responsible for a significant proportion of epithelial ovarian tumours in which oestrogen receptor alpha expression is lost.

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