Custom DNA-binding Proteins Come of Age: Polydactyl Zinc-finger Proteins

Overview

Journal Curr Opin Biotechnol

Publisher Elsevier

Specialty Biotechnology

Date 2002 Feb 19

PMID 11849947

Citations 33

Authors

D J Segal

C F Barbas 3rd

Affiliations

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Abstract

Artificial transcription factors based on modified zinc-finger DNA-binding domains have been shown to activate or repress the transcription of endogenous genes in multiple organisms. Advances in both the construction of novel zinc-finger proteins and our understanding of the characteristics of a productive regulatory site have fueled these achievements.

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