Surprisingly Small Effect of Antiviral Treatment in Patients with Hepatitis C

Overview

Journal Ann Intern Med

Specialty General Medicine

Date 2002 Feb 19

PMID 11848726

Citations 100

Authors

Yngve Falck-Ytter

Hemangi Kale

Kevin D Mullen

Steedman A Sarbah

Lucian Sorescu

Arthur J McCullough

Affiliations

Soon will be listed here.

Abstract

Background: The effect and applicability of interferon-based antiviral therapies in the general population of persons with hepatitis C virus (HCV) infection are unknown.

Objective: To determine the applicability and usefulness of anti-viral therapy in a metropolitan clinic population.

Design: Retrospective case series of consecutively referred patients.

Setting: A teaching county hospital in Cleveland, Ohio.

Patients: 327 patients referred to a liver clinic after a positive result for antibody against HCV on enzyme-linked immunosorbent assay (ELISA).

Measurements: Treatment rates; reasons for nontreatment.

Results: 34 patients had no detectable HCV RNA. Of the remaining 293 patients, 72% were not treated for the following reasons: 37% did not adhere to evaluation procedures, 34% had medical or psychiatric contraindications, 13% had ongoing substance or alcohol abuse, 11% preferred no treatment, and 5% had normal liver enzyme levels. Only 83 patients (28%) were treated; 13% had a sustained viral response.

Conclusion: Most patients with HCV infection are not candidates for interferon-based therapies; alternative interventions should be sought for these patients.

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