Leishmania Major Promastigotes Inhibit Dendritic Cell Motility in Vitro

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2002 Jan 18

PMID 11796645

Citations 12

Authors

Heather Jebbari

Andrew J Stagg

Robert N Davidson

Stella C Knight

Affiliations

Soon will be listed here.

Abstract

Using an in vitro transwell migration assay, we have demonstrated that products secreted by Leishmania major promastigotes inhibit the motility of dendritic cells (DC) by up to 93%. Inhibition was dose dependent and reversible. By inhibiting DC migration in vivo, L. major may therefore subvert DC from their potentially protective role during leishmaniasis.

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