Understanding Cytotoxic T-lymphocyte Escape During Simian Immunodeficiency Virus Infection

Overview

Journal Immunol Rev

Specialties Allergy & Immunology
General Surgery

Date 2002 Jan 10

PMID 11782252

Citations 18

Authors

D OConnor

T Friedrich

A Hughes

T M Allen

D Watkins

Affiliations

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Abstract

Infection of rhesus macaques with simian immunodeficiency virus (SIV) is an excellent model system for studying viral adaptation to immune responses. In this review, we discuss how the SIV-infected macaque has provided unequivocal evidence for cytotoxic T-lymphocyte (CTL) selection of viral escape variants. This improved understanding of CTL escape may influence human immunodeficiency virus (HIV) vaccine design as well as our understanding of HIV pathogenesis.

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