Estrogen Receptors and Endocrine Diseases: Lessons from Estrogen Receptor Knockout Mice

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2002 Jan 5

PMID 11757817

Citations 37

Authors

S O Mueller

K S Korach

Affiliations

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Abstract

The estrogen receptors ERalpha and ERbeta are the main mediators of estrogen action and estrogens play an important role in a variety of aspects of physiology besides their well acknowledged function in reproduction. In vivo and in vitro studies indicate that the estrogen receptors are mechanistically implicated in endocrine-related diseases. Recent studies with estrogen receptor knockout mice have helped to unravel the role of the estrogen receptors in brain degeneration, osteoporosis, cardiovascular diseases and obesity.

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