JNK Functions in the Non-canonical Wnt Pathway to Regulate Convergent Extension Movements in Vertebrates

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2001 Dec 26

PMID 11751577

Citations 185

Authors

Hiroaki Yamanaka

Tetsuo Moriguchi

Norihisa Masuyama

Morioh Kusakabe

Hiroshi Hanafusa

Ritsuko Takada

Shinji Takada

Eisuke Nishida

Affiliations

Soon will be listed here.

Abstract

Recent genetic studies in Drosophila identified a novel non-canonical Wnt pathway, the planar cell polarity (PCP) pathway, that signals via JNK to control epithelial cell polarity in Drosophila. Most recently, a pathway regulating convergent extension movements during gastrulation in vertebrate embryos has been shown to be a vertebrate equivalent of the PCP pathway. However, it is not known whether the JNK pathway functions in this non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. In addition, it is not known whether JNK is in fact activated by Wnt stimulation. Here we show that Wnt5a is capable of activating JNK in cultured cells, and present evidence that the JNK pathway mediates the action of Wnt5a to regulate convergent extension movements in Xenopus. Our results thus demonstrate that the non-canonical Wnt/JNK pathway is conserved in both vertebrate and invertebrate and define that JNK has an activity to regulate morphogenetic cell movements.

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