Alpha 2.0
Login Register
» Articles » PMID: 117500

Antinociceptive Effects of Central and Systemic Administrations of Nicotine in the Rat

Overview
Journal Psychopharmacology (Berl)
Specialty Pharmacology
Date 1979 Nov 1
PMID 117500
Citations 37
Authors
T L Sahley
G G Berntson
Affiliations
Soon will be listed here.
Abstract

Nicotine (0.16--0.50 mg/kg, SC) was found to exert a potent antinociceptive action on thermal stimuli as measured by the tail-flick test. This antinociceptive action of nicotine could be blocked by centrally active nicotinic or muscarinic blockers implicating both classes of cholinergic receptors in this effect. Quaternary blockers, however, failed to prevent nicotine-induced antinociception. This finding, together with the ability of small doses of nicotine (25 micrograms) to induce potent antinociceptive effects when administered centrally, suggests a central site of action for the antinociceptive action of nicotine. The present results also support the suggestion that nicotine may selectively reduce sensitivity to certain classes of pain stimuli, perhaps through a central releasing action on acetylcholine.

Citing Articles

Anti-Inflammatory, Antinociceptive, and LC-MS Metabolic Profile from (Klatt) Lovo & A. Gil.

Minho A, Almeida P, Kato N, Brand A, Vieira R, Garrett R Pharmaceuticals (Basel). 2024; 17(8).

PMID: 39204205 PMC: 11359133. DOI: 10.3390/ph17081101.

Acute nicotine treatment enhances compulsive-like remifentanil self-administration that persists despite contextual punishment.

Honeycutt S, Paladino M, Camadine R, Mukherjee A, Loney G Addict Biol. 2022; 27(3):e13170.

PMID: 35470562 PMC: 9175303. DOI: 10.1111/adb.13170.

Two New -Alkanoyl-5-Hydroxytryptamides with Relevant Antinociceptive Activity.

Amorim J, Lima F, Brand A, Cunha S, Rezende C, Fernandes P Biomedicines. 2021; 9(5).

PMID: 33922159 PMC: 8146016. DOI: 10.3390/biomedicines9050455.

Pharmacological Evaluation of Crude CO Subcritical Extract after the Removal of Santonin by Means of High Speed Countercurrent Chromatography.

Sakipova Z, Giorno T, Bekezhanova T, Siu Hai Wong N, Shukirbekova A, Fernandes P Molecules. 2020; 25(12).

PMID: 32545512 PMC: 7355858. DOI: 10.3390/molecules25122728.

: Identification of the Anti-Inflammatory and Antinociceptive Effects.

da Costa Salome D, Cordeiro N, Sequeira Valerio T, de Alexandria Santos D, Barreto Alves P, Alviano C Biomedicines. 2020; 8(5).

PMID: 32384613 PMC: 7277703. DOI: 10.3390/biomedicines8050111.

References
1.
Pert A, Maxey G . Asymmetrical cross-tolerance between morphine and scopolamine induced antinociception in the primate: differential sites of action. Psychopharmacologia. 1975; 44(2):139-45. DOI: 10.1007/BF00421000. View
2.
Kaakkola S, Ahtee L . Effect of muscarinic cholinergic drugs on morphine-induced catalepsy, antinociception and changes in brain dopamine metabolism. Psychopharmacology (Berl). 1977; 52(1):7-15. DOI: 10.1007/BF00426593. View
3.
Pedigo N, Dewey W, Harris L . Determination and characterization of the antinociceptive activity of intraventricularly administered acetylcholine in mice. J Pharmacol Exp Ther. 1975; 193(3):845-52. View
4.
Morrison C . The modification by physostigmine of some effects of nicotine on bar-pressing behaviour of rats. Br J Pharmacol Chemother. 1968; 32(1):28-33. PMC: 1570283. DOI: 10.1111/j.1476-5381.1968.tb00426.x. View
5.
Mattila M, Ahtee L, Saarnivaara L . The analgesic and sedative effects of nicotine in white mice, rabbits and golden hamsters. Ann Med Exp Biol Fenn. 1968; 46(1):78-84. View