Comparison of the Behavioral Effects of Cigarette Smoke and Pure Nicotine in Rats

Overview

Journal Pharmacol Biochem Behav

Publisher Elsevier

Specialties Biochemistry
Pharmacology
Psychology
Social Sciences

Date 2010 May 25

PMID 20494826

Citations 29

Authors

Andrew C Harris

Christina Mattson

Mark G Lesage

Daniel E Keyler

Paul R Pentel

Affiliations

Soon will be listed here.

Abstract

Animal models of tobacco dependence typically rely on parenteral administration of pure nicotine. Models using cigarette smoke inhalation might more accurately simulate nicotine exposure in smokers. The primary goal of this study was to validate methods for administering cigarette smoke to rats using exposure conditions that were clinically relevant and also produced brain nicotine levels similar to those produced by behaviorally active doses of pure nicotine. A secondary goal was to begin examining the behavioral effects of smoke. Nose-only exposure (NOE) to smoke for 10-45min or whole-body exposure (WBE) to smoke for 1-4h produced serum nicotine concentrations similar to those in smokers (14-55ng/ml), without excessive carbon monoxide exposure. Daily nicotine (0.1mg/kg, s.c.) induced locomotor sensitization whereas 45-min NOE producing brain nicotine levels within the same range did not. Nicotine 0.125mg/kg s.c. reversed withdrawal from a chronic nicotine infusion as measured by elevations in intracranial self-stimulation thresholds whereas 4-h WBE producing similar brain nicotine levels did not. These data demonstrate the feasibility of delivering cigarette smoke to rats at clinically relevant doses, and provide preliminary evidence that the behavioral effects of nicotine delivered in smoke may differ from those of pure nicotine.

Citing Articles

Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats.

Harris A, Muelken P, Alcheva A, Stepanov I, Lesage M Front Neurosci. 2022; 16:868088.

PMID: 35712461 PMC: 9196039. DOI: 10.3389/fnins.2022.868088.

Biologically Active Compounds Present in Tobacco Smoke: Potential Interactions Between Smoking and Mental Health.

Hong S, Teesdale-Spittle P, Page R, Ellenbroek B, Truman P Front Neurosci. 2022; 16:885489.

PMID: 35557609 PMC: 9087043. DOI: 10.3389/fnins.2022.885489.

β-Carbolines found in cigarette smoke elevate intracranial self-stimulation thresholds in rats.

Harris A, Muelken P, Lesage M Pharmacol Biochem Behav. 2020; 198:173041.

PMID: 32926882 PMC: 7554228. DOI: 10.1016/j.pbb.2020.173041.

Non-nicotine constituents in e-cigarette aerosol extract attenuate nicotine's aversive effects in adolescent rats.

Harris A, Muelken P, Swain Y, Palumbo M, Jain V, Goniewicz M Drug Alcohol Depend. 2019; 203:51-60.

PMID: 31404849 PMC: 6941564. DOI: 10.1016/j.drugalcdep.2019.05.023.

Neurobiological and Neurophysiological Mechanisms Underlying Nicotine Seeking and Smoking Relapse.

Schmidt H, Rupprecht L, Addy N Mol Neuropsychiatry. 2019; 4(4):169-189.

PMID: 30815453 PMC: 6388439. DOI: 10.1159/000494799.

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