SLC11A1 (formerly NRAMP1) and Disease Resistance

Overview

Journal Cell Microbiol

Publisher Wiley

Specialties Cell Biology
Microbiology

Date 2001 Dec 12

PMID 11736990

Citations 97

Authors

J M Blackwell

T Goswami

C A Evans

D Sibthorpe

N Papo

J K White

S Searle

E N Miller

C S Peacock

H Mohammed

M Ibrahim

Affiliations

Soon will be listed here.

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Association of SLC11A1 polymorphisms with anthropometric and biochemical parameters describing Type 2 Diabetes Mellitus.

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References

Soo S, Villarreal-Ramos B, Khan C, Hormaeche C, Blackwell J . Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge. Infect Immun. 1998; 66(5):1910-7. PMC: 108143. DOI: 10.1128/IAI.66.5.1910-1917.1998. View

Hirsch E, Faucheux B . Iron metabolism and Parkinson's disease. Mov Disord. 1998; 13 Suppl 1:39-45. View

Shaw M, Collins A, Peacock C, Miller E, Black G, Sibthorpe D . Evidence that genetic susceptibility to Mycobacterium tuberculosis in a Brazilian population is under oligogenic control: linkage study of the candidate genes NRAMP1 and TNFA. Tuber Lung Dis. 1997; 78(1):35-45. DOI: 10.1016/s0962-8479(97)90014-9. View

Hackam D, Rotstein O, Zhang W, Gruenheid S, Gros P, Grinstein S . Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med. 1998; 188(2):351-64. PMC: 2212455. DOI: 10.1084/jem.188.2.351. View

Searle S, Bright N, Roach T, Atkinson P, Barton C, Meloen R . Localisation of Nramp1 in macrophages: modulation with activation and infection. J Cell Sci. 1998; 111 ( Pt 19):2855-66. DOI: 10.1242/jcs.111.19.2855. View

Garner B, Roberg K, Brunk U . Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress. Free Radic Res. 1998; 29(2):103-14. DOI: 10.1080/10715769800300121. View

Esposito L, Hill N, Pritchard L, Cucca F, Muxworthy C, Merriman M . Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group. Diabetes. 1998; 47(11):1797-9. DOI: 10.2337/diabetes.47.11.1797. View

Shiloh M, MacMicking J, Nicholson S, Brause J, Potter S, Marino M . Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity. 1999; 10(1):29-38. DOI: 10.1016/s1074-7613(00)80004-7. View

Zwilling B, Kuhn D, Wikoff L, Brown D, Lafuse W . Role of iron in Nramp1-mediated inhibition of mycobacterial growth. Infect Immun. 1999; 67(3):1386-92. PMC: 96472. DOI: 10.1128/IAI.67.3.1386-1392.1999. View

10.

Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam D, Grinstein S, Gros P . The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med. 1999; 189(5):831-41. PMC: 2192949. DOI: 10.1084/jem.189.5.831. View

11.

Blackwell J, Searle S . Genetic regulation of macrophage activation: understanding the function of Nramp1 (=Ity/Lsh/Bcg). Immunol Lett. 1999; 65(1-2):73-80. DOI: 10.1016/s0165-2478(98)00127-8. View

12.

Strausak D, La Fontaine S, Hill J, Firth S, Lockhart P, Mercer J . The role of GMXCXXC metal binding sites in the copper-induced redistribution of the Menkes protein. J Biol Chem. 1999; 274(16):11170-7. DOI: 10.1074/jbc.274.16.11170. View

13.

Searle S, Blackwell J . Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J Med Genet. 1999; 36(4):295-9. PMC: 1734346. View

14.

Francis M, Jones E, Levy E, Martin R, Ponnambalam S, Monaco A . Identification of a di-leucine motif within the C terminus domain of the Menkes disease protein that mediates endocytosis from the plasma membrane. J Cell Sci. 1999; 112 ( Pt 11):1721-32. DOI: 10.1242/jcs.112.11.1721. View

15.

Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P . Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999; 93(12):4406-17. View

16.

Ambrosini L, Mercer J . Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease. Hum Mol Genet. 1999; 8(8):1547-55. DOI: 10.1093/hmg/8.8.1547. View

17.

Kuhn D, Baker B, Lafuse W, Zwilling B . Differential iron transport into phagosomes isolated from the RAW264.7 macrophage cell lines transfected with Nramp1Gly169 or Nramp1Asp169. J Leukoc Biol. 1999; 66(1):113-9. DOI: 10.1002/jlb.66.1.113. View

18.

Voskoboinik I, Strausak D, Greenough M, Brooks H, Petris M, Smith S . Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells. J Biol Chem. 1999; 274(31):22008-12. DOI: 10.1074/jbc.274.31.22008. View

19.

Agranoff D, Monahan I, Mangan J, Butcher P, Krishna S . Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family. J Exp Med. 1999; 190(5):717-24. PMC: 2195619. DOI: 10.1084/jem.190.5.717. View

20.

Petris M, Mercer J . The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal. Hum Mol Genet. 1999; 8(11):2107-15. DOI: 10.1093/hmg/8.11.2107. View