How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues

Overview

Journal Trends Microbiol

Date 2020 Aug 19

PMID 32807623

Citations 9

Authors

Anne-Beatrice Blanc-Potard

Eduardo A Groisman

Affiliations

Soon will be listed here.

Abstract

Host organisms utilize nutritional immunity to limit the availability of nutrients essential to an invading pathogen. Nutrients may include amino acids, nucleotide bases, and transition metals, the essentiality of which varies among pathogens. The mammalian macrophage protein Slc11a1 (previously Nramp1) mediates resistance to several intracellular pathogens. Slc11a1 is proposed to restrict growth of Salmonella enterica serovar Typhimurium in host tissues by causing magnesium deprivation. This is intriguing because magnesium is the most abundant divalent cation in all living cells. A pathogen's response to factors such as Slc11a1 that promote nutritional immunity may therefore reflect what the pathogen 'feels' in its cytoplasm, rather than the nutrient concentration in host cell compartments.

Citing Articles

Analyzing the Responses of Enteric Bacteria to Neonatal Intensive Care Supplements.

Waller M, Eichhorn C, Gutierrez A, Baatz J, Wagner C, Chetta K Int J Microbiol. 2024; 2024:3840327.

PMID: 39220439 PMC: 11364479. DOI: 10.1155/2024/3840327.

Metalloproteome plasticity - a factor in bacterial pathogen adaptive responses?.

McEwan A Emerg Top Life Sci. 2024; 8(1):57-60.

PMID: 38323345 PMC: 10903460. DOI: 10.1042/ETLS20230116.

How Bacterial Pathogens Coordinate Appetite with Virulence.

Pokorzynski N, Groisman E Microbiol Mol Biol Rev. 2023; 87(3):e0019822.

PMID: 37358444 PMC: 10521370. DOI: 10.1128/mmbr.00198-22.

The elements of life: A biocentric tour of the periodic table.

Remick K, Helmann J Adv Microb Physiol. 2023; 82:1-127.

PMID: 36948652 PMC: 10727122. DOI: 10.1016/bs.ampbs.2022.11.001.

Genomic Characterization of Salmonella enterica serovar Weltevreden Associated with Human Diarrhea.

Zhang J, Peng Z, Chen K, Zhan Z, Shen H, Feng S Microbiol Spectr. 2023; 11(1):e0354222.

PMID: 36651774 PMC: 9927414. DOI: 10.1128/spectrum.03542-22.

References

Grass G, Franke S, Taudte N, Nies D, Kucharski L, Maguire M . The metal permease ZupT from Escherichia coli is a transporter with a broad substrate spectrum. J Bacteriol. 2005; 187(5):1604-11. PMC: 1064025. DOI: 10.1128/JB.187.5.1604-1611.2005. View

Park M, Kim H, Nam D, Kweon D, Shin D . The mRNA Leader Secures Growth of in Both Host and Non-host Environments. Front Microbiol. 2019; 10:2831. PMC: 6908480. DOI: 10.3389/fmicb.2019.02831. View

Pontes M, Lee E, Choi J, Groisman E . Salmonella promotes virulence by repressing cellulose production. Proc Natl Acad Sci U S A. 2015; 112(16):5183-8. PMC: 4413311. DOI: 10.1073/pnas.1500989112. View

Cuellar-Mata P, Jabado N, Liu J, Furuya W, Finlay B, Gros P . Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages. J Biol Chem. 2001; 277(3):2258-65. DOI: 10.1074/jbc.M105508200. View

Cunrath O, Bumann D . Host resistance factor SLC11A1 restricts growth through magnesium deprivation. Science. 2019; 366(6468):995-999. DOI: 10.1126/science.aax7898. View

Sheldon J, Skaar E . Metals as phagocyte antimicrobial effectors. Curr Opin Immunol. 2019; 60:1-9. PMC: 6800623. DOI: 10.1016/j.coi.2019.04.002. View

Alpuche Aranda C, Swanson J, Loomis W, MILLER S . Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes. Proc Natl Acad Sci U S A. 1992; 89(21):10079-83. PMC: 50281. DOI: 10.1073/pnas.89.21.10079. View

Romani A . Magnesium homeostasis in Mammalian cells. Met Ions Life Sci. 2013; 12:69-118. DOI: 10.1007/978-94-007-5561-1_4. View

Solomon F, Kayser J, Groisman E . The SPI-3 pathogenicity island of Salmonella enterica. J Bacteriol. 1999; 181(3):998-1004. PMC: 93469. DOI: 10.1128/JB.181.3.998-1004.1999. View

10.

Cromie M, Shi Y, Latifi T, Groisman E . An RNA sensor for intracellular Mg(2+). Cell. 2006; 125(1):71-84. DOI: 10.1016/j.cell.2006.01.043. View

11.

Amer A, Swanson M . A phagosome of one's own: a microbial guide to life in the macrophage. Curr Opin Microbiol. 2002; 5(1):56-61. DOI: 10.1016/s1369-5274(02)00286-2. View

12.

Groisman E, Hollands K, Kriner M, Lee E, Park S, Pontes M . Bacterial Mg2+ homeostasis, transport, and virulence. Annu Rev Genet. 2013; 47:625-46. PMC: 4059682. DOI: 10.1146/annurev-genet-051313-051025. View

13.

Yeom J, Shao Y, Groisman E . Small proteins regulate survival inside macrophages by controlling degradation of a magnesium transporter. Proc Natl Acad Sci U S A. 2020; 117(33):20235-20243. PMC: 7443967. DOI: 10.1073/pnas.2006116117. View

14.

Sheldon J, Laakso H, Heinrichs D . Iron Acquisition Strategies of Bacterial Pathogens. Microbiol Spectr. 2016; 4(2). DOI: 10.1128/microbiolspec.VMBF-0010-2015. View

15.

Martin-Orozco N, Touret N, Zaharik M, Park E, Kopelman R, Miller S . Visualization of vacuolar acidification-induced transcription of genes of pathogens inside macrophages. Mol Biol Cell. 2005; 17(1):498-510. PMC: 1345685. DOI: 10.1091/mbc.e04-12-1096. View

16.

Choi J, Groisman E . expresses foreign genes during infection by degrading their silencer. Proc Natl Acad Sci U S A. 2020; 117(14):8074-8082. PMC: 7149492. DOI: 10.1073/pnas.1912808117. View

17.

Popp J, Noster J, Busch K, Kehl A, Zur Hellen G, Hensel M . Role of host cell-derived amino acids in nutrition of intracellular Salmonella enterica. Infect Immun. 2015; 83(12):4466-75. PMC: 4645403. DOI: 10.1128/IAI.00624-15. View

18.

Wessling-Resnick M . Nramp1 and Other Transporters Involved in Metal Withholding during Infection. J Biol Chem. 2015; 290(31):18984-90. PMC: 4521020. DOI: 10.1074/jbc.R115.643973. View

19.

Zwir I, Latifi T, Christian Perez J, Huang H, Groisman E . The promoter architectural landscape of the Salmonella PhoP regulon. Mol Microbiol. 2012; 84(3):463-85. PMC: 3335776. DOI: 10.1111/j.1365-2958.2012.08036.x. View

20.

Ganz T . Iron and infection. Int J Hematol. 2017; 107(1):7-15. DOI: 10.1007/s12185-017-2366-2. View