Capsid Protein Gene Variation Among Feline Calicivirus Isolates

Overview

Journal Virus Genes

Specialties Microbiology
Molecular Biology

Date 2001 Nov 29

PMID 11724270

Citations 5

Authors

T Horimoto

Y Takeda

K Iwatsuki-Horimoto

S Sugii

T Tajima

Affiliations

Soon will be listed here.

Abstract

We amplified the capsid protein gene fragments of 30 Japanese isolates of feline calicivirus (FCV), including the C, D, and E regions, by reverse transcription-polymerase chain reaction (RT-PCR), followed by direct sequencing. Alignment of the predicted amino acid sequences, together with other published sequences from the isolates obtained in other countries, demonstrated a marked heterogeneity among the isolates, confirming the current definition of hypervariable regions within the capsid protein: these regions give rise to the antigenic variations seen in FCV isolates. Phylogenetic analysis of the nucleotide sequences could not identify significant geographically or temporally separated clusters of FCV isolates, supporting the theory of a single genotype.

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