Preparation of 5-substituted 1H-tetrazoles from Nitriles in Water

Overview

Journal J Org Chem

Publisher American Chemical Society

Specialty Chemistry

Date 2001 Nov 28

PMID 11722189

Citations 68

Authors

Z P Demko

K B Sharpless

Affiliations

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Abstract

The addition of sodium azide to nitriles to give 1H-tetrazoles is shown to proceed readily in water with zinc salts as catalysts. The scope of the reaction is quite broad; a variety of aromatic nitriles, activated and unactivated alkyl nitriles, substituted vinyl nitriles, thiocyanates, and cyanamides have all been shown to be viable substrates for this reaction.

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