» Articles » PMID: 11716351

Endoplasmic Reticulum in the Heart, a Forgotten Organelle?

Overview
Publisher Springer
Specialty Biochemistry
Date 2001 Nov 22
PMID 11716351
Citations 8
Authors
Affiliations
Soon will be listed here.
Abstract

Our hypothesis is that sarcoplasmic and endoplasmic reticulum Ca2+ stores may be functionally distinct compartments in cardiomyocytes. Sarcoplasmic reticulum Ca2+ store is responsible for control of excitation-contraction coupling whereas endoplasmic reticulum compartment may provide Ca2+ for housekeeping and transcriptional functions.

Citing Articles

Calreticulin expression in human cardiac myocytes induces ER stress-associated apoptosis.

Stoner M, McTiernan C, Scott I, Manning J Physiol Rep. 2020; 8(8):e14400.

PMID: 32323496 PMC: 7177173. DOI: 10.14814/phy2.14400.


Calreticulin is a secreted BMP antagonist, expressed in Hensen's node during neural induction.

De Almeida I, Oliveira N, Randall R, Hill C, McCoy J, Stern C Dev Biol. 2016; 421(2):161-170.

PMID: 27919666 PMC: 5231319. DOI: 10.1016/j.ydbio.2016.12.001.


Tauroursodeoxycholic acid inhibits endoplasmic reticulum stress, blocks mitochondrial permeability transition pore opening, and suppresses reperfusion injury through GSK-3ß in cardiac H9c2 cells.

Xie Y, He Y, Cai Z, Cai J, Xi M, Zhang Y Am J Transl Res. 2016; 8(11):4586-4597.

PMID: 27904664 PMC: 5126306.


Calreticulin in the heart.

Michalak M, Guo L, Robertson M, Lozak M, Opas M Mol Cell Biochem. 2016; 263(1):137-42.

PMID: 27520672 DOI: 10.1023/B:MCBI.0000041855.10149.5f.


New concepts of endoplasmic reticulum function in the heart: programmed to conserve.

Doroudgar S, Glembotski C J Mol Cell Cardiol. 2012; 55:85-91.

PMID: 23085588 PMC: 3557761. DOI: 10.1016/j.yjmcc.2012.10.006.


References
1.
John L, Lechleiter J, Camacho P . Differential modulation of SERCA2 isoforms by calreticulin. J Cell Biol. 1998; 142(4):963-73. PMC: 2132884. DOI: 10.1083/jcb.142.4.963. View

2.
Flucher B, Franzini-Armstrong C . Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle. Proc Natl Acad Sci U S A. 1996; 93(15):8101-6. PMC: 38882. DOI: 10.1073/pnas.93.15.8101. View

3.
Sutko J, Airey J . Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function?. Physiol Rev. 1996; 76(4):1027-71. DOI: 10.1152/physrev.1996.76.4.1027. View

4.
Fliegel L, Newton E, Burns K, Michalak M . Molecular cloning of cDNA encoding a 55-kDa multifunctional thyroid hormone binding protein of skeletal muscle sarcoplasmic reticulum. J Biol Chem. 1990; 265(26):15496-502. View

5.
Harvey R . NK-2 homeobox genes and heart development. Dev Biol. 1996; 178(2):203-16. DOI: 10.1006/dbio.1996.0212. View