Hypoxia and Oxidative Stress in Breast Cancer. Hypoxia Signalling Pathways

Overview

Journal Breast Cancer Res

Specialty Oncology

Date 2001 Oct 13

PMID 11597320

Citations 16

Authors

C W Pugh

J Gleadle

P H Maxwell

Affiliations

Soon will be listed here.

Abstract

Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.

Citing Articles

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