HIF-1, O(2), and the 3 PHDs: How Animal Cells Signal Hypoxia to the Nucleus

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2001 Oct 12

PMID 11595178

Citations 315

Authors

G L Semenza

Affiliations

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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a global regulator of cellular and systemic O(2) homeostasis in animals. A molecular basis for O(2)-regulated expression of the HIF-1 alpha subunit has now been determined, providing a mechanism for changes in gene expression in response to changes in cellular oxygenation.

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