Increased Synthesis of Low-molecular-weight Nuclear Ribonucleic Acids of Rat Liver After Gamma Irradiation and Hepatectomy

Overview

Journal Biochem J

Specialty Biochemistry

Date 1975 Feb 1

PMID 1156376

Authors

A Fonagy

E J HIDVEGI

Affiliations

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Abstract

Incorporation of [3H]orotic acid into low-molecular-weight nRNA of rat liver, fractionated on polyacrylamide gels, increased 6-12h after partial hepatectomy and 6h after gamma-irridation at 2000 R. The incorporation of orotic acid was particularly increased into the 4.5S, 5S and approx. 10S nRNA fractions. If the irradiation was given after 6h of regeneration and RNA was isolated from the nucleus 12h after hepatectomy then the incorporation of orotic acid into these low-molecular-weight nRNA components was greater than after hepatectomy or irradiation alone.

References

Lieberman I, Kane P . SYNTHESIS OF RIBOSOMES IN THE LIVER AFTER PARTIAL HEPATECTOMY. J Biol Chem. 1965; 240:1737-41. View

Muramatsu M, Busch H . Studies on the nuclear and nucleolar ribonucleic acid of regenerating rat liver. J Biol Chem. 1965; 240(10):3960-6. View

Fujioka M, Koga M, Lieberman I . METABOLISM OF RIBONUCLEIC ACID AFTER PARTIAL HEPATECTOMY. J Biol Chem. 1963; 238:3401-6. View

HOLBROOK Jr D, Evans J, IRVIN J . Incorporation of labeled precursors into proteins and nucleic acids of nuclei of regenerating liver. Exp Cell Res. 1962; 28:120-5. DOI: 10.1016/0014-4827(62)90319-1. View

Grisham J . A morphologic study of deoxyribonucleic acid synthesis and cell proliferation in regenerating rat liver; autoradiography with thymidine-H3. Cancer Res. 1962; 22:842-9. View

Peacock A, DINGMAN C . Resolution of multiple ribonucleic acid species by polyacrylamide gel electrophoresis. Biochemistry. 1967; 6(6):1818-27. DOI: 10.1021/bi00858a033. View

HIDVEGI E, Holland J, BOLONI E, Lonai P, Antoni F, VARTERESZ V . The effect of whole-body x-irradiation of guinea pigs on liver ribosomes. Biochem J. 1968; 109(4):495-505. PMC: 1186935. DOI: 10.1042/bj1090495. View

Baeyens W, GOUTIER R . Effect of total-body x-irradiation on the properties of polyribosomes in normal rat liver. Arch Int Physiol Biochim. 1968; 76(4):785-96. DOI: 10.3109/13813456809058741. View

Weinberg R, Penman S . Metabolism of small molecular weight monodisperse nuclear RNA. Biochim Biophys Acta. 1969; 190(1):10-29. DOI: 10.1016/0005-2787(69)90150-6. View

10.

CAMMARANO P, Giudice G, LUKES B . POLYRIBOSOMES IN REGENERATING LIVER. Biochem Biophys Res Commun. 1965; 19:487-93. DOI: 10.1016/0006-291x(65)90151-8. View

11.

STEELE W, Okamura N, Busch H . EFFECTS OF THIOACETAMIDE ON THE COMPOSITION AND BIOSYNTHESIS OF NUCLEOLAR AND NUCLEAR RIBONUCLEIC ACID IN RAT LIVER. J Biol Chem. 1965; 240:1742-9. View

12.

Popov P, HADJIOLOV A . Effect of irradiation on the biosynthesis of liver ribonucleic acids in intact and adrenalectomized rats. Z Naturforsch B. 1971; 26(12):1282-7. DOI: 10.1515/znb-1971-1217. View

13.

Omata S, Ichii S, YAGO N . Effects of whole-body x-irradiation on nuclear RNA polymerase activities in rat tissues. J Biochem. 1968; 63(6):695-700. DOI: 10.1093/oxfordjournals.jbchem.a128833. View

14.

Redy R, Henning D, Takano T, Taylor C, Busch H . Nucleotide sequence of 4.5 S ribonucleic acid of Novikoff hepatoma cell nuclei. J Biol Chem. 1972; 247(10):3205-22. View

15.

Moriyama Y, HODNETT J, Prestayko A, Busch H . Studies on the nuclear 4 to 7 s RNA of the Novikoff hepatoma. J Mol Biol. 1969; 39(2):335-49. DOI: 10.1016/0022-2836(69)90321-0. View

16.

Nakamura T, Prestayko A, Busch H . Studies on nucleolar 4 to 6 S ribonucleic acid of Novikoff hepatoma cells. J Biol Chem. 1968; 243(7):1368-75. View

17.

Loening U . The fractionation of high-molecular-weight ribonucleic acid by polyacrylamide-gel electrophoresis. Biochem J. 1967; 102(1):251-7. PMC: 1270235. DOI: 10.1042/bj1020251. View

18.

SNOSWELL A, HENDERSON G . Aspects of carnitine ester metabolism in sheep liver. Biochem J. 1970; 119(1):59-65. PMC: 1179318. DOI: 10.1042/bj1190059. View

19.

HIDVEGI E, BOLONI E, Holland J, Antoni F, VARTERESZ V . The effect of whole-body x-irradiation of guinea pigs on liver ribonucleic acid synthesis. Biochem J. 1970; 116(3):503-14. PMC: 1185388. DOI: 10.1042/bj1160503. View

20.

Yatvin M . RNA polymerase activity in liver nuclei of intact and adrenalectomized gamma-irradiated mice. Experientia. 1970; 26(5):490. DOI: 10.1007/BF01898462. View