» Articles » PMID: 11562504

Mechanisms of Pain

Overview
Specialty Science
Date 2001 Sep 20
PMID 11562504
Citations 33
Authors
Affiliations
Soon will be listed here.
Abstract

Persistent or chronic pain is the primary reason people seek medical care, yet current therapies are either inadequate for certain types of pain or cause intolerable side effects. Recently, pain neurobiologists have identified a number of cellular and molecular processes that lead to the initiation and maintenance of pain. Understanding these underlying mechanisms has given significant promise for the development of more effective, more specific pain therapies in the near future.

Citing Articles

Efficacy of Duloxetine for Postspine Surgery Pain: A Systematic Review and Meta-Analysis.

Aleid A, Alshehri F, Alasiri N, Alhomoud F, Alsaegh S, Alrasheed M Brain Behav. 2024; 15(1):e70217.

PMID: 39740780 PMC: 11688044. DOI: 10.1002/brb3.70217.


Advancing Pain Understanding and Drug Discovery: Insights from Preclinical Models and Recent Research Findings.

Asiri Y, Moni S, Ramar M, Chidambaram K Pharmaceuticals (Basel). 2024; 17(11).

PMID: 39598351 PMC: 11597627. DOI: 10.3390/ph17111439.


Imaging of Pain using Positron Emission Tomography.

Zhou Y, Zhang L, Sun Y, Brugarolas P iRadiology. 2024; 2(3):339-361.

PMID: 39440326 PMC: 11493400. DOI: 10.1002/ird3.73.


Sensors and Devices Guided by Artificial Intelligence for Personalized Pain Medicine.

Xing Y, Yang K, Lu A, Mackie K, Guo F Cyborg Bionic Syst. 2024; 5:0160.

PMID: 39282019 PMC: 11395709. DOI: 10.34133/cbsystems.0160.


Clinical Characteristics and Local Histopathological Modulators of Endometriosis and Its Progression.

Istrate-Ofiteru A, Mogoanta C, Zorila G, Rosu G, Dragusin R, Berbecaru E Int J Mol Sci. 2024; 25(3).

PMID: 38339066 PMC: 10855449. DOI: 10.3390/ijms25031789.


References
1.
Averill S, McMahon S, Clary D, Reichardt L, Priestley J . Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons. Eur J Neurosci. 1995; 7(7):1484-94. PMC: 2758238. DOI: 10.1111/j.1460-9568.1995.tb01143.x. View

2.
Bennett D, Michael G, Ramachandran N, Munson J, Averill S, Yan Q . A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury. J Neurosci. 1998; 18(8):3059-72. PMC: 6792585. View

3.
Kellstein D, Price D, MAYER D . Cholecystokinin and its antagonist lorglumide respectively attenuate and facilitate morphine-induced inhibition of C-fiber evoked discharges of dorsal horn nociceptive neurons. Brain Res. 1991; 540(1-2):302-6. DOI: 10.1016/0006-8993(91)90524-y. View

4.
Watson C . The treatment of neuropathic pain: antidepressants and opioids. Clin J Pain. 2000; 16(2 Suppl):S49-55. DOI: 10.1097/00002508-200006001-00009. View

5.
McCleskey E, Gold M . Ion channels of nociception. Annu Rev Physiol. 1999; 61:835-56. DOI: 10.1146/annurev.physiol.61.1.835. View